Results 171 to 180 of about 658,680 (315)

DEVELOPMENT OF ATLAS-BASED STRATEGIES FOR THE ANALYSIS OF NEURODEGENERATIVE PATHOLOGIES USING PET/MRI [PDF]

openOne of the most interesting future research prospects in the field of PET/MRI imaging is the development of quantitative automated or semi-automated methods for the analysis of neurodegenerative diseases, this projects can be hampered by the lack of ...
DORNO, GIAN MARCO
core  

The time interval from amyloid to tau PET positivity varies by age, sex and APOE-ε4 status. [PDF]

J Prev Alzheimers Dis
Milà-Alomà M, Hausle I, Petersen KK, Thropp P, Schindler SE, Tosun D, Alzheimer’s Disease Neuroimaging Initiative.   +6 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Optimization of PET-CT protocol with [18F]-Choline in the study of parathyroid glands [PDF]

reservedQuesto lavoro di tesi esplora il ruolo della PET/CT con [^18F] Colina nell'individuazione delle patologie paratiroidee, analizzando le caratteristiche del radiofarmaco, inclusi i suoi aspetti cinetici, biodistribuzione ed eliminazione.
FISHTA, GJOANA
core  

PET-MR Examination in Diagnosing Bone Metastases in Prostate Cancer. [PDF]

Cancer Manag Res
Su X, Li K, Wang J, Jiang Z, Shan L.
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Clinico-biological trajectories stratified by combined tau biomarkers in preclinical Alzheimer's disease. [PDF]

Alzheimers Res Ther
Labrador-Espinosa MA, Franzmeier N, Karagianni S, Moscoso A, Schöll M.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Limitations in diagnostics and quantification of small lesions with low uptake in the clinical context of prostate ¹⁸F/⁶⁸Ga-PSMA PET/MRI. [PDF]

EJNMMI Phys
Lindemann ME, Jentzen W, Küper A, Costa PF, Gratz M, Umutlu L, Nagarajah J, Nekolla SG, Rausch I, Herrmann K, Quick HH, Kersting D.   +11 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source