Results 161 to 170 of about 779,565 (306)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Clinical Utility of 18F-FDG PET/CT for Staging and Restaging of Pediatric Malignant Melanoma: A Single-Center Retrospective Study. [PDF]

Children (Basel)
Isik EG, Kebudi R.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Association of Amyloid-β and Tau With Synaptic Dysfunction in Alzheimer's Disease. [PDF]

Ann Clin Transl Neurol
Roveta F, Mendes AJ, Garibotto V, Boccalini C, Lathuiliere A, Rainero I, Rubino E, Zetterberg H, Ashton NJ, Ribaldi F, Frisoni GB, Alzheimer's Disease Neuroimaging Initiative.   +11 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Role of PET/CT in diffuse large B-cell lymphoma (Review). [PDF]

Mol Clin Oncol
Jing H, Shao H, Zhou D, Bi L.
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

PET imaging for ion beam therapy monitoring

openRicerche sull'impiego della tomografia ad emissione di positroni (PET) per il monitoraggio della terapia con fasci di ioni con ioni leggeri e più pesanti sono iniziati poco dopo la prima realizzazione di planari e sistemi di imaging tomografico.
MELCHIONDA, MARTINA
core  

Impact of reduced scan extent on tumor detection in ⁶⁸Ga-PSMA PET/CT for biochemical recurrence of prostate cancer. [PDF]

BMC Med Imaging
Gühne F, Küppers A, Kühnel C, Seifert P, Freesmeyer M.   +4 more
europepmc   +1 more source