Results 91 to 100 of about 307,140 (314)

Preoperative Imaging of Charcot Neuroarthropathy in Diabetic Patients: Comparison of Ring PET, Hybrid PET, and Magnetic Resonance Imaging [PDF]

, 2004
Introduction: The treatment of Charcot neuroarthropathy in the feet of diabetic patients has undergone fundamental changes in the last few years. Formerly, treatment was almost exclusively limited to nonoperative measures; since the late 1990s, however ...
Tiling, Reinhold, Krolak, Christoph, Dresel, Stefan, Höpfner, Stefan, Kessler, Stefan, Brinkbäumer, Kirsten, Hahn, Klaus   +6 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Feasibility of simultaneous PET-MR perfusion using a novel cardiac perfusion phantom

European Journal of Hybrid Imaging, 2017
Background PET-MR scanners are beginning to be employed for quantitative myocardial perfusion imaging. In order to examine simultaneous perfusion calculations, this work describes a feasibility study of simultaneous PET-MR of gadolinium-based contrast ...
Jim O’Doherty, Eva Sammut, Paul Schleyer, James Stirling, Muhummad Sohaib Nazir, Paul K. Marsden, Amedeo Chiribiri   +6 more
doaj   +1 more source

Development of new radiopharmaceutical for molecular imaging in oncology [PDF]

, 2011
De afgelopen jaren zijn diverse nieuwe geneesmiddelen tegen kanker ontwikkeld. Er kan echter nog niet goed vooraf voorspeld worden bij welke patiënt deze nieuwe geneesmiddelen zullen werken.
Dijkers, Eli Carl Ferre,, Dijkers, Eli Carl Ferre   +1 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Molecular imaging using positron emission tomography in gastrointestinal malignancy

, 2010
Positron Emission Tomography (PET) with 18F-FDG has emerged as a powerful tool in oncology. Furthermore, recent advent of PET/CT and novel tracers are continually expanding its role.
Pakzad, F.
core  

PET Studies of Cerebral Levodopa Metabolism: A Review of Clinical Findings and Modeling Approaches [PDF]

, 2009
[18F]Fluoro-3,4-dihydroxyphenyl-l-alanine (FDOPA) was one of the first successful tracers for molecular imaging by positron emission tomography (PET), and has proven immensely valuable for studies of Parkinson’s disease.
Kumakura, Yoshitaka, Yoshitaka Kumakura, Paul Cumming, Cumming, Paul   +3 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

[11C]-L-Methionine positron emission tomography in the management of children and young adults with brain tumors

, 2009
Only a few Methyl-[11C]-l-methionine (MET) positron emission tomography (PET) studies have focused on children and young adults with brain neoplasm. Due to radiation exposure, long scan acquisition time, and the need for sedation in young children MET ...
Johannes C. Klein, Frank Berthold, Kracht, L., Heiss, Wolf-Dieter, Herholz, Karl; id_orcid, Galldiks, N., Herholz, Karl, Klein, Johannes C., Heiss, Wolf Dieter, Jacobs, Andreas H., Hrvoje Miletic, Heiss, W., Lutz W. Kracht, Wolf-Dieter Heiss, Berthold, Frank, Klein, Johannes Christian, Jacobs, A., Kracht, Lutz W., Karl Herholz, Galldiks, Norbert, Miletic, Hrvoje, Herholz, K., Berthold, F., Norbert Galldiks, Klein, J., Kracht, Lutz Walter, Andreas H. Jacobs, Miletic, H.   +27 more
core   +1 more source