Results 71 to 80 of about 2,246,984 (309)

τBu₂SiF-Derivatized D₂-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging [PDF]

, 2011
The synthesis, radiolabeling and in vitro evaluation of new silicon-fluoride acceptor (SiFA) derivatized D-2-receptor ligands is reported. The SiFA-technology simplifies the introduction of fluorine-18 into target specific biomolecules for Positron ...
Wängler, Carmen, Zöller, Thomas, Schirrmacher, Ralf, Christian Rensch, Klaus Theodor Wanner, Ljuba Iovkova-Berends, Thomas Zöller, Alexey Kostikov, Jurkschat, Klaus, Höfner, Georg, Kostikov, Alexey, Wängler, Björn, Wanner, Klaus Theodor, Klaus Jurkschat, Ralf Schirrmacher, Iovkova-Berends, Ljuba, Björn Wängler, Carmen Wängler, Georg Höfner, Peter Bartenstein, Rensch, Christian, Bartenstein, Peter   +21 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Hybrid MR-PET Imaging: Systems, Methods and Applications

, 2022
Using molecules radiolabelled with positron emitters, positron emission tomography (PET) imaging provides information relating to a multitude of physiological and metabolic functions.
Hans Herzog, Hidehiro Iida, Liliana Calderia   +2 more
core   +1 more source

Towards consensus in acquisition and image analysis of PET and SPECT in the assessment of cardiac sympathetic innervation: a mini-review [PDF]

, 2022
In the rapidly evolving field of nuclear medicine, imaging cardiac sympathetic innervation using both conventional nuclear medicine and PET tracers is a small but growing field of interest.
Walter Noordzij, Luis E. Juarez‑Orozco, Andor W. J. M. Glaudemans, Riemer H. J. A. Slart   +3 more
core   +1 more source

Misery perfusion and amyloid deposition in atherosclerotic major cerebral artery disease

NeuroImage: Clinical, 2019
Although experimental studies have shown that global cerebral hypoperfusion leads to amyloid deposition in the hemisphere with carotid artery occlusion in rodents, the results of such occurrence are controversial in humans.
Hiroshi Yamauchi, Shinya Kagawa, Masaaki Takahashi, Naoya Oishi, Masahiro Ono, Tatsuya Higashi   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Radiomic Analysis of Striatal [ 18F]FDOPA PET Imaging in Patients with Psychosis for the Identification of Antipsychotic Response

PURPOSE: Schizophrenia (SCZ) is a severe psychiatric disorder marked by abnormal dopamine synthesis, measurable through [ 18F]FDOPA PET imaging. This imaging technique has been proposed as a biomarker for treatment stratification in SCZ, where one ...
Andrea Bettinelli, Rubaida Easmin, Steven Williams, Giovanna Nordio, (FDOPA PET imaging working group), Astrid Schiulaz, Pierluigi Selvaggi, Sameer Jauhar, Federico Turkheimer, Oliver Howes, Mattia Veronese, Alessio Giacomel   +11 more
core   +1 more source

Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan

Journal of Biomedical Physics and Engineering, 2019
Background: Compact cyclotrons are getting popular to fulfill enormous current demands of PET tracers. Aga Khan University Hospital, Karachi, Pakistan has acquired the first smallest footprint of BG-75 Generator for 18FDG-based PET/CT clinical imaging.
Zaman M. U., Fatima N., Mehdi S. U., Sami M., Khan Kh., Khan G.   +5 more
doaj