Results 61 to 70 of about 307,140 (314)

Normalising Brain PET Images [PDF]

, 2007
PET is a nuclear medical examination which constructs a three-dimensional image of metabolism inside the body; in this article is particular, images are taken from the brain. The high complexity inherent to the interpretation of the brain images makes that any help is important to the specialists in order to accurate the diagnostic.
Elia Ferrando Juliá, Daniel Ruiz Fernández, Antonio Soriano Payá   +2 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

τBu₂SiF-Derivatized D₂-Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging [PDF]

, 2011
The synthesis, radiolabeling and in vitro evaluation of new silicon-fluoride acceptor (SiFA) derivatized D-2-receptor ligands is reported. The SiFA-technology simplifies the introduction of fluorine-18 into target specific biomolecules for Positron ...
Wängler, Carmen, Zöller, Thomas, Schirrmacher, Ralf, Christian Rensch, Klaus Theodor Wanner, Ljuba Iovkova-Berends, Thomas Zöller, Alexey Kostikov, Jurkschat, Klaus, Höfner, Georg, Kostikov, Alexey, Wängler, Björn, Wanner, Klaus Theodor, Klaus Jurkschat, Ralf Schirrmacher, Iovkova-Berends, Ljuba, Björn Wängler, Carmen Wängler, Georg Höfner, Peter Bartenstein, Rensch, Christian, Bartenstein, Peter   +21 more
core   +1 more source

Hybrid MR-PET Imaging: Systems, Methods and Applications

, 2022
Using molecules radiolabelled with positron emitters, positron emission tomography (PET) imaging provides information relating to a multitude of physiological and metabolic functions.
Hans Herzog, Hidehiro Iida, Liliana Calderia   +2 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Assessment of test-retest reproducibility by [18F]Bavarostat for PET imaging of HDAC6

EJNMMI Research
Background Histone deacetylase 6 (HDAC6) is an enzyme pivotal for gene regulation, influencing cellular pathways through protein deacetylation. HDAC6 is a potential therapeutic target in diseases such as cancer and neurodegenerative disorders.
Mika Naganawa, Ming-Qiang Zheng, Jean-Dominique Gallezot, Robin Bonomi, Jiwei Gu, Hong Gao, Swanee Jacutin-Porte, Nabeel B. Nabulsi, Michel Koole, Koen Van Laere, David Matuskey, Yiyun Huang, Richard E. Carson   +12 more
doaj   +1 more source

Assessment of different regions of interest-based methods for [99mTc]Tc DAT-SPECT quantification using an anthropomorphic striatal phantom

EJNMMI Physics, 2022
Background and aims Molecular imaging of the dopamine transporters (DAT) provides valuable information about neurodegenerative diseases, such as Parkinson’s. This study assessed the accuracy and precision of DAT-SPECT quantification methods.
Leonardo Alexandre-Santos, Ana Carolina Trevisan, Felipe Arriva Pitella, Vitor Tumas, Jose Henrique Silvah, Mery Kato, Eder Rezende de Moraes, Lauro Wichert-Ana   +7 more
doaj   +1 more source

Projector Model for Efficient List-Mode Reconstruction in PET Scanners with Parallel Planar Detectors

, 2011
We have developed a new projector model specifically tailored for fast list-mode tomographic reconstructions in Positron emission tomography (PET) scanners with parallel planar detectors.
Sportelli, Giancarlo, Guerra Gutiérrez, Pedro, Andres Santos, Santos Lleo, Andres de, Pedro Guerra, Guerra, P, Juan E. Ortuno, Giancarlo Sportelli, Ortuño Fisac, Juan Enrique, Santos, A., Ortuno, JE   +10 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Imaging of atherosclerosis with [64Cu]Cu-DOTA-TATE in a translational head-to-head comparison study with [18F]FDG, and Na[18F]F in rabbits

Scientific Reports, 2023
Atherosclerosis is a chronic inflammatory disease of the larger arteries that may lead to cardiovascular events. Identification of patients at highest risk of cardiovascular events is challenging, but molecular imaging using positron emission tomography (
Constance E. Grandjean, Sune F. Pedersen, Camilla Christensen, Altea Dibenedetto, Thomas Eriksen, Tina Binderup, Andreas Kjaer   +6 more
doaj   +1 more source