Results 41 to 50 of about 503,675 (296)

The Search for a Subtype-Selective PET Imaging Agent for the GABA Receptor Complex: Evaluation of the Radiotracer [C]ADO in Nonhuman Primates

Molecular Imaging, 2017
The myriad physiological functions of γ-amino butyric acid (GABA) are mediated by the GABA-benzodiazepine receptor complex comprising of the GABA A , GABA B , and GABA C groups.
Shu-fei Lin PhD, Frederic Bois PhD, Daniel Holden BA, Nabeel Nabulsi PhD, Richard Pracitto MS, Hong Gao MS, Michael Kapinos BS, Jo-ku Teng BS, Anupama Shirali PhD, Jim Ropchan PhD, Richard E. Carson PhD, Charles S. Elmore PhD, Neil Vasdev PhD, Yiyun Huang PhD   +13 more
doaj   +1 more source

Cessation of anti-VLA-4 therapy in a focal rat model of multiple sclerosis causes an increase in neuroinflammation

EJNMMI Research, 2019
Background Positron emission tomography (PET) can be used for in vivo evaluation of the pathology associated with multiple sclerosis. We investigated the use of longitudinal PET imaging and the 18-kDa translocator protein (TSPO) binding radioligand [18F ...
S. K. Vainio, A. M. Dickens, J. Tuisku, O. Eskola, O. Solin, E. Löyttyniemi, D. C. Anthony, J. O. Rinne, L. Airas, M. Haaparanta-Solin   +9 more
doaj   +1 more source

J-PET: a new technology for the whole-body PET imaging [PDF]

, 2017
The Jagiellonian Positron Emission Tomograph (J-PET) is the first PET built from plastic scintillators. J-PET prototype consists of 192 detection modules arranged axially in three layers forming a cylindrical diagnostic chamber with the inner diameter of
Białas, P., Curceanu, C., Czerwiński, E., Dulski, K., Gajos, A., Gorgol, M., Głowacz, B., Hiesmayr, B. C., Jasińska, B., Kapłon, Ł., Kisielewska-Kamińska, D., Korcyl, G., Kowalski, P., Kozik, T., Krawczyk, N., Krzemień, W., Kubicz, E., Mohammed, M., Moskal, P., Niedźwiecki, S., Pawlik-Niedźwiecka, M., Pałka, M., Raczyński, L., Rudy, Z., Sharma, N. G., Sharma, S., Shopa, R. Y., Silarski, M., Skurzok, M., Wieczorek, A., Wiślicki, W., Zgardzińska, B., Zieliński, M.   +32 more
core   +2 more sources

Data-driven analysis of kappa opioid receptor binding in major depressive disorder measured by positron emission tomography

Translational Psychiatry, 2021
Preclinical studies have implicated kappa opioid receptors (KORs) in stress responses and depression-related behaviors, but evidence from human studies is limited.
Kelly Smart, Ashley Yttredahl, Maria A. Oquendo, J. John Mann, Ansel T. Hillmer, Richard E. Carson, Jeffrey M. Miller   +6 more
doaj   +1 more source

Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA

EJNMMI Research
Background P2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [11C]SMW139 is the most recently developed radiotracer to image P2X7 receptor.
Obada M. Alzghool, Richard Aarnio, Jatta S. Helin, Saara Wahlroos, Thomas Keller, Markus Matilainen, Junel Solis, Jonathan J. Danon, Michael Kassiou, Anniina Snellman, Olof Solin, Juha O. Rinne, Merja Haaparanta-Solin   +12 more
doaj   +1 more source

Stability evaluation of [18F]FDG: literature study, stability studies from two different PET centres and future recommendations

EJNMMI Radiopharmacy and Chemistry, 2022
Background The need for a stability evaluation of [18F]FDG is evident. The main purpose of this study was to make recommendations for determining the shelf life based on the available stability literature and our own two-centre stability studies. Results
Jes G. Holler, Børge Renmælmo, Richard Fjellaksel   +2 more
doaj   +1 more source

Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. [PDF]

, 2012
PurposeAs imaging of the cell surface tetraspan protein epithelial membrane protein-2 (EMP2) expression in malignant tumors may provide important prognostic and predictive diagnostic information, the goal of this study is to determine if antibody ...
Braun, Jonathan, Brewer, Sarah, Fu, Maoyong, Gordon, Lynn K, Olafsen, Tove, Said, Jonathan, Wadehra, Madhuri, Wu, Anna M   +7 more
core   +3 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Isolated single lobe hyperplasia of the thyroid gland, presenting as anterior mediastinal mass, detected on positron emission tomography-computed tomography scan

World Journal of Nuclear Medicine, 2020
We report a case who presented with facial swelling and breathlessness. Recent chest X-ray was suggestive of soft-tissue in the mediastinum. In view of the suspicion of mass being neoplastic, the patient was referred for positron emission tomography ...
Nitin Gupta, Dharmender Malik, Ritu Verma, Sunila Jain   +3 more
doaj   +1 more source

Attenuation correction for brain PET imaging using deep neural network based on dixon and ZTE MR images

, 2018
Positron Emission Tomography (PET) is a functional imaging modality widely used in neuroscience studies. To obtain meaningful quantitative results from PET images, attenuation correction is necessary during image reconstruction. For PET/MR hybrid systems,
Fakhri, Georges El, Gong, Kuang, Kim, Kyungsang, Li, Quanzheng, Seo, Youngho, Yang, Jaewon   +5 more
core   +1 more source