Results 81 to 90 of about 2,246,984 (309)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

In vivo imaging of cellular proliferation in colorectal cancer using positron emission tomography [PDF]

, 2003
Background and aims: Positron emission tomography (PET) using 18F labelled 2-fluoro-2-deoxy-D-glucose (18FDG) is an established imaging tool, although the recent development of a biologically stable thymidine analogue [18F] 3'-deoxy-3-fluorothymidine ...
Costa, D.C., Ell, P.J., Luthra, S.K., Taylor, I., Francis, D.L., Freeman, A., Novelli, M., Visvikis, D.   +7 more
core  

[11C]-L-Methionine positron emission tomography in the management of children and young adults with brain tumors [PDF]

, 2009
Only a few Methyl-[11C]-l-methionine (MET) positron emission tomography (PET) studies have focused on children and young adults with brain neoplasm. Due to radiation exposure, long scan acquisition time, and the need for sedation in young children MET ...
Johannes C. Klein, Frank Berthold, Kracht, L., Heiss, Wolf-Dieter, Herholz, Karl; id_orcid, Galldiks, N., Herholz, Karl, Klein, Johannes C., Heiss, Wolf Dieter, Jacobs, Andreas H., Hrvoje Miletic, Heiss, W., Lutz W. Kracht, Wolf-Dieter Heiss, Berthold, Frank, Klein, Johannes Christian, Jacobs, A., Kracht, Lutz W., Karl Herholz, Galldiks, Norbert, Miletic, Hrvoje, Herholz, K., Berthold, F., Norbert Galldiks, Klein, J., Kracht, Lutz Walter, Andreas H. Jacobs, Miletic, H.   +27 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

CT-PET guided target delineation in head and neck cancer and implications for improved outcome [PDF]

, 2010
Aim: Fifty percent of patients with squamous cell carcinoma of the Head and Neck develop loco-regional recurrence after treatment. Factors leading to this failure are most likely altered intra-tumoural glucose metabolism and increased hypoxia ...
Moule, R.N.
core  

Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions

EJNMMI Research, 2019
Background Cimbi-36 can be 11C-labeled to form an agonist radioligand used for positron emission tomography (PET) imaging of the 5-HT2A receptor in the brain.
Annette Johansen, Søren Holm, Bente Dall, Sune Keller, Jesper L. Kristensen, Gitte M. Knudsen, Hanne D. Hansen   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Evaluation of a PET Insert for Trimodal Imaging: A Step Towards PET/MRI-Guided Focused Ultrasound [PDF]

[EN] Combining Positron Emission Tomography (PET) with Magnetic Resonance Imaging (MRI) and Focused Ultrasound (FUS) has emerged as a promising hybrid technique in the medical imaging field.
Camarena Femenia, Francisco, Rispoli, J.V, Alonso-Otamendi, Joseba, Jimenez, Noe, Berr, S. S., Gil-Cervera, Marc, Algarín-Guisado, José Miguel, Pallás-Lodeiro, Eduardo, González-Tamarit, A., Loignon-Houle, F., Vidal San Sebastian, Luis Fernando, Rodríguez-Álvarez, M.J., Torres, I., Jiménez-Serrano, Santiago, Demir, Z.E.F., Thede, A., CARRIÓN GARCÍA, ALICIA, Sheybani, N. D., Hoch, M., Bosch-Esteve, Rubén, Sachs, J.L., Andrés, D., Maslova, S., Williams, M. B., Alonso-Ramos, José Luis, González Martínez, Antonio Javier, Gonzalez-Montoro, Andrea, Sherlock, T., He, J., Freire-López-Fando, Marta, Lopez-Berenguer, F., Tustison, N., Rodríguez-García, Juan José, Guallart-Naval, T., Benlloch Baviera, Jose María   +34 more
core   +1 more source