Results 31 to 40 of about 337 (145)
Nature Communications, 2022 Increased density of tumor associated macrophages has been correlated with tumor recurrence following surgery. Here the authors design an alginate-based hydrogel encapsulating anti-PD-1-conjugated platelets and nanoparticles loaded with the macrophage ...
Zhaoting Li +9 more
doaj +1 more source
Evaluation of Absorption and Metabolism-Based DDI Potential of Pexidartinib in Healthy Subjects
Clinical Pharmacokinetics, 2022 Pexidartinib is a novel oral small-molecule inhibitor that selectively targets colony-stimulating factor 1 receptor, KIT proto-oncogene receptor tyrosine kinase, and FMS-like tyrosine kinase 3 harboring an internal tandem duplication mutation. It is approved in the United States for the treatment of adult patients with symptomatic tenosynovial giant ...
Hamim Zahir +5 more
openaire +2 more sources
Population pharmacokinetic analysis of pexidartinib in healthy subjects and patients with tenosynovial giant cell tumor or other solid tumors [PDF]
, 2020 Pexidartinib is a kinase inhibitor that induces tumor response and improvements in symptoms and functional outcomes in adult patients with symptomatic tenosynovial giant cell tumor (TGCT).
Zahir, H. +10 more
core +1 more source
Drugs in R&D, 2020 Tenosynovial giant cell tumor is a rare proliferative tumor that arises from the synovium, bursae, or tendon sheaths due to an overproduction of colony-stimulating factor 1.
Shanada Monestime, Dovena Lazaridis
doaj +1 more source
Continual Deletion of Spinal Microglia Reforms Astrocyte Scar Favoring Axonal Regeneration
Frontiers in Pharmacology, 2022 Astrocyte scar formation after spinal cord injury (SCI) efficiently limits the accurate damage but physically restricts the following axon regeneration. Lately, fine tuning scar formation is becoming a novel strategy to develop SCI treatment, yet how to ...
Longkuo Xia +21 more
doaj +1 more source
Journal of Neuroinflammation, 2023 Graft-versus-host disease (GVHD) is a serious complication of otherwise curative allogeneic haematopoietic stem cell transplants. Chronic GVHD induces pathological changes in peripheral organs as well as the brain and is a frequent cause of late ...
Samreen N. Shaikh +9 more
doaj +1 more source
A qualitative evaluation of patient and healthcare provider knowledge, attitudes, and behavior for safety and use of pexidartinib [PDF]
Journal of Comparative Effectiveness Research, 2021 Aim: Pexidartinib is approved in the USA for the treatment of symptomatic tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to improvement with surgery. Due to risk of serious liver injury, a survey of patient and healthcare provider (HCP) knowledge, attitudes, and ...
Maribel Salas +7 more
openaire +2 more sources
Activated microglia and neuroinflammation as a pathogenic mechanism in Leigh syndrome
Frontiers in Neuroscience, 2023 Neuroinflammation is one of the main mechanisms leading to neuronal death and dysfunction in neurodegenerative diseases. The role of microglia as primary mediators of inflammation is unclear in Leigh syndrome (LS) patients.
Nastaran Daneshgar +5 more
doaj +1 more source
Overview of Pharmacological Therapies for Diffuse Tenosynovial Giant Cell Tumor
Future Pharmacology, 2023 Tenosynovial giant cell tumor (TGCT) is a rare and locally aggressive benign tumor arising from the synovium of joints, bursae, and tendon sheaths. It is classified into localized (L-TGCT) and diffuse (D-TGCT) forms based on the extent of involvement ...
Antonia Stamatiou +7 more
doaj +1 more source
Microglia depletion prevents lactation by inhibition of prolactin secretion
iScience, 2023 Summary: Microglial cells were eliminated from the brain with sustained 3–4 weeks long inhibition of colony stimulating factor 1 receptor by Pexidartinib 3397 (PLX3397). The prepartum treated mice mothers did not feed their pups after parturition.
Vivien Csikós +5 more
doaj +1 more source