Results 31 to 40 of about 22,023 (250)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Profiles of Kelch mutations in Plasmodium falciparum across South Asia and their implications for tracking drug resistance

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Artemisinin-based combination therapy (ACT) offers highly successful treatment of malaria. Emergence and spread of Plasmodium falciparum (Pf) parasites with decreased susceptibility to ACT in South-East Asia has caused concern worldwide.
Jyoti Chhibber-Goel, Amit Sharma
doaj   +1 more source

Comparative Evaluation of the Angiogenic Potential of Hypoxia Preconditioned Blood-Derived Secretomes and Platelet-Rich Plasma: An In Vitro Analysis

Biomedicines, 2020
Blood-derived factor preparations are being clinically employed as tools for promoting tissue repair and regeneration. Here we set out to characterize the in vitro angiogenic potential of two types of frequently used autologous blood-derived secretomes ...
Philipp Moog, Katharina Kirchhoff, Sanjar Bekeran, Anna-Theresa Bauer, Sarah von Isenburg, Ulf Dornseifer, Hans-Günther Machens, Arndt F. Schilling, Ektoras Hadjipanayi   +8 more
doaj   +1 more source

Spectral Study of some Charge Transfer Complexes Derived from Schiff base of 3- Methoxy -4-hydroxy benzaldehyde with some Electrone acceptors. [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
:A new series of Schiff bases were obtained by condensation of 3- methoxy -4-hydroxy benzaldehyde (vanillin) with seven aromatic amine .These bases were identified by infrared spectra and melting point .
Laila A. Jubur, Abdul-Rahman K. Abdul-Hussain   +1 more
doaj   +1 more source

Ferrocene-Containing Pseudorotaxanes in Crystals: Aromatic Interactions with Hammett Correlation

Molecules, 2022
Single crystals of pseudorotaxanes, [(FcCH2NH2CH2Ar)(DB24C8)][PF6] (DB24C8 = dibenzo[24]crown-8, Fc = Fe(C5H4)(C5H5), Ar = -C6H3-3,4-Cl2, -C6H3-3,4-F2, -C6H4-4-F, -C6H4-4-Cl, -C6H4-4-Br, -C6H3-3-F-4-Me, -C6H4-4-I) and [(FcCH2NH2CH2C6H4-4-Me)(DB24C8)][Ni ...
Yuji Suzaki, Tomoko Abe, Asami Takei, Yugo Fukuchi, Take-aki Koizumi, Kohtaro Osakada, Masaki Horie   +6 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Expanding the chemical space of flavins with pentacyclic architecture

Nature Communications
Inspired by the prominent redox and optical properties of natural flavins, synthetic flavins have found broad applications in organic, photochemical, and biochemical research. Tailoring these properties of flavins, however, remains a challenge.
Dayeong Seo, Seongyeon Kwon, Gahye Yoon, Taeil Son, Changhyeon Won, Neetu Singh, Dongwook Kim, Yunjung Baek   +7 more
doaj   +1 more source

Systematic study on the static Robinson instability in an electron storage ring

Physical Review Accelerators and Beams, 2023
The static Robinson instability and associated coherent synchrotron frequencies were systematically studied at the Photon Factory (PF) 2.5-GeV storage ring at KEK. Under machine parameters close to an anticipated Robinson limit, we observed beam dumps at
Takaaki Yamaguchi, Shogo Sakanaka, Naoto Yamamoto, Daichi Naito, Takeshi Takahashi   +4 more
doaj   +1 more source

A Novel Direct-Fed Microbial for Beef Cattle Has a Supportive Effect against Clostridium perfringens In Vitro and In Vivo

Ruminants, 2023
Two experiments were conducted to evaluate the in vitro and in vivo effects of a novel direct-fed microbial (DFM) containing Lactobacillus animalis LA-51, Propionibacterium freudenreichii PF-24, Bacillus licheniformis CH-200, and Bacillus subtilis King ...
Octavio Guimaraes, Bruno I. Cappellozza, Lena C. Capern, Jennifer S. Schutz, Charley A. Cull, Oscar Queiroz, Giuseppe Copani   +6 more
doaj   +1 more source