Results 41 to 50 of about 604,221 (250)

Expanding the chemical space of flavins with pentacyclic architecture

Nature Communications
Inspired by the prominent redox and optical properties of natural flavins, synthetic flavins have found broad applications in organic, photochemical, and biochemical research. Tailoring these properties of flavins, however, remains a challenge.
Dayeong Seo, Seongyeon Kwon, Gahye Yoon, Taeil Son, Changhyeon Won, Neetu Singh, Dongwook Kim, Yunjung Baek   +7 more
doaj   +1 more source

Systematic study on the static Robinson instability in an electron storage ring

Physical Review Accelerators and Beams, 2023
The static Robinson instability and associated coherent synchrotron frequencies were systematically studied at the Photon Factory (PF) 2.5-GeV storage ring at KEK. Under machine parameters close to an anticipated Robinson limit, we observed beam dumps at
Takaaki Yamaguchi, Shogo Sakanaka, Naoto Yamamoto, Daichi Naito, Takeshi Takahashi   +4 more
doaj   +1 more source

A Novel Direct-Fed Microbial for Beef Cattle Has a Supportive Effect against Clostridium perfringens In Vitro and In Vivo

Ruminants, 2023
Two experiments were conducted to evaluate the in vitro and in vivo effects of a novel direct-fed microbial (DFM) containing Lactobacillus animalis LA-51, Propionibacterium freudenreichii PF-24, Bacillus licheniformis CH-200, and Bacillus subtilis King ...
Octavio Guimaraes, Bruno I. Cappellozza, Lena C. Capern, Jennifer S. Schutz, Charley A. Cull, Oscar Queiroz, Giuseppe Copani   +6 more
doaj   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Perbaikan Retensi Air dengan Aplikasi Bahan Organik pada Pertanaman Sorgum

Jurnal Ilmu Pertanian Indonesia
This study aimed to determine the role of water hyacinth (Eichhornia crassipes Mart.) organic matter on water retention at pF 2.54 and pF 4.2, available water content, and bulk density (BD).
Nurmi Nurmi, Nikmah Musa, Zulzain Ilahude   +2 more
doaj   +1 more source

Effect of Hypoxia Preconditioned Secretomes on Lymphangiogenic and Angiogenic Sprouting: An in Vitro Analysis

Biomedicines, 2020
Hypoxia Preconditioned Plasma (HPP) and Serum (HPS) are two blood-derived autologous growth factor compositions that are being clinically employed as tools for promoting tissue regeneration, and have been extensively examined for their angiogenic ...
Philipp Moog, Rahmin Schams, Alexander Schneidinger, Arndt F. Schilling, Hans-Günther Machens, Ektoras Hadjipanayi, Ulf Dornseifer   +6 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Identification of putative regulatory motifs in the upstream regions of co-expressed functional groups of genes in Plasmodium falciparum

BMC Genomics, 2009
Background Regulation of gene expression in Plasmodium falciparum (Pf) remains poorly understood. While over half the genes are estimated to be regulated at the transcriptional level, few regulatory motifs and transcription regulators have been found ...
Joshi NV, Iengar Prathima
doaj   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

Multi-omics analysis reveals RNA polymerase II degradation as a novel mechanism of PF-3758309’s anti-tumor activity

Cell Death Discovery
PF-3758309, a pyrrolopyrimidine-based inhibitor of p21-activated kinase 4 (PAK4), has demonstrated preclinical anti-tumor activity. However, due to poor pharmacokinetics and off-target effects, it has not advanced to clinical use.
Xinglong Jia, Jingdan Zhang, Lulu Pan, Jingliang He, Mingrui Zhu, Lei Zhao, Xingyu Zhang, Wensi Zhao, Dong Xie, Xiaoyan Shen, Bin Liu, Minjia Tan   +11 more
doaj   +1 more source