Results 31 to 40 of about 170,636 (309)

Structure of the Plasmodium falciparum PfA-M17_Co4 (3KR5)

, 2016
<div>Current therapeutics and prophylactics for malaria are under severe challenge as a result of the rapid emergence of drug-resistant parasites.
Sheena McGowan (23652)
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

PFA concrete:chloride-induced reinforcement corrosion

, 1994
The Paper describes a study undertaken to determine the effect of PFA on reinforcement corrosion due to chlorides in concrete. The results indicate that the time to corrosion initiation when PFA is included is greatly increased, but that the quantity of ...
Jones, Martyn; id_orcid, McCarthy, Michael; id_orcid, Dhir, Ravindra   +2 more
core   +1 more source

Prey-capture efficiency between juveniles and adults, feeding habitat and abundance of Wattled Jacana foragers in northern Pantanal, Mato Grosso state, Brazil

Brazilian Journal of Biology
The choice of foraging strategies implies an attempt at gaining energy by predators. Supposedly, the difference in employing the "sit and wait" or "active foraging" behavior lays in hunter skills, experience and the kind of prey consumed.
LR Forti, PFA Nóbrega
doaj   +1 more source

Sensitive and specific assessment of recombinant von Willebrand factor in platelet function analyzer

Platelets, 2019
Background: Recombinant von Willebrand factor (rVWF), which was licensed in the United States in 2015, has the multimeric distribution of freshly secreted VWF with ultralarge (UL) and high molecular weight multimers (HMWM) from endothelial cells and ...
Isabell Pekrul, Thorsten Kragh, Peter L Turecek, Aaron R Novack, Helmut W Ott, Michael Spannagl   +5 more
doaj   +1 more source

The myth of the 1-day training: the effectiveness of psychosocial support capacity-building during the Ebola outbreak in West Africa

Cambridge Prisms: Global Mental Health, 2019
Background.In emergencies and resource-poor settings, non-specialists are increasingly being trained to provide psychosocial support to people in distress, with Psychological First Aid (PFA) one of the most widely-used approaches.
Rebecca Horn, Fiona O'May, Rebecca Esliker, Wilfred Gwaikolo, Lise Woensdregt, Leontien Ruttenberg, Alastair Ager   +6 more
doaj   +1 more source

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening. [PDF]

PLoS ONE, 2015
The Plasmodium falciparum PfA-M1 and PfA-M17 metalloaminopeptidases are validated drug targets for the discovery of antimalarial agents. In order to identify dual inhibitors of both proteins, we developed a hierarchical virtual screening approach ...
Chiara Ruggeri, Nyssa Drinkwater, Komagal Kannan Sivaraman, Rebecca S Bamert, Sheena McGowan, Alessandro Paiardini   +5 more
doaj   +1 more source

Plant Feed Additives as Natural Alternatives to the Use of Synthetic Antioxidant Vitamins on Yield, Quality, and Oxidative Status of Poultry Products: A Review of the Literature of the Last 20 Years

Antioxidants, 2021
Scientific evidence demonstrates that plant feed additives (PFA) can be a viable alternative to synthetic antioxidant vitamins in poultry nutrition.
Rosario Pitino, Massimo De Marchi, Carmen L. Manuelian, Marion Johnson, Marica Simoni, Federico Righi, Eleni Tsiplakou   +6 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Developing targeted therapies for pediatric PFA ependymoma [PDF]

PFA ependymomas are highly aggressive brain tumors typically arising in young children (median age 3 years) and characterized by a poor outcome (10-year OS < 60%).
Jenseit, Anne Lena
core   +1 more source