Results 141 to 150 of about 29,031 (266)
ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals
Advanced Science, EarlyView.The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray +3 more
wiley +1 more source
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang +12 more
wiley +1 more source
Sustainable Materials Design With Multi‐Modal Artificial Intelligence
Advanced Science, EarlyView.Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu +8 more
wiley +1 more source
Effects of PFAS on the physiology of freshwater arthropods
openI composti perfluoroalchilici, o PFAS, sono delle sostanze inquinanti largamente utilizzate nell'industria grazie alla loro forte stabilità e a caratteristiche come idrofobicità e lipofobicità.
ROMANELLO, LEONARDO
core
Advanced Science, EarlyView.This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang +11 more
wiley +1 more source
Study of transgenerational effects of PFAS pollution in Poecilia reticulata
reservedLo scopo dello studio è indagare la presenza di effetti transgenerazionali di due diversi PFAS in Poecilia reticulata. I PFAS usati sono GenX (2,3,3,3-tetrafluoro-2-(eptafluoropropossi)-propanoato di ammonio) e PFOA (Acido perfluoroottanoico) e,
LEONARDI, FRANCESCO EUGENIO
core
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
PFAS and Health: Evidence, Impact, and Management Strategies at the ULSS 8 Berica Health Authority
openL’inquinamento ambientale rappresenta una delle principali sfide per la salute pubblica contemporanea. Tra le sostanze emergenti, le sostanze perfluoroalchiliche (PFAS) hanno attirato crescente attenzione per la loro persistenza nell’ambiente e la ...
GUARDA, LUCA
core
Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants
Advanced Science, EarlyView.The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann +11 more
wiley +1 more source
Not everywhere, not always: 30 targeted PFAS in ambient surface waters of Queensland, Australia. [PDF]
Environ Monit AssessBaddiley B, Myburgh A, Vardy S.
europepmc +1 more source