Results 21 to 30 of about 27,275 (312)
Emerging and legacy PFAS and cytokine homeostasis in women of childbearing age
Scientific Reports, 2022 Per- and polyfluoroalkyl substances (PFAS) are widespread chemicals. Legacy PFAS have been phased out of production in most developed countries and emerging PFAS (short-chain PFAS and polyfluorinated compounds) are used as legacy PFAS alternatives.
Min Nian +5 more
doaj +1 more source
Quantification of PFAS in soils treated with biosolids in ten northeastern US farms
Scientific ReportsThis study, one of the few conducted to date on working farms in the US, examined per- and polyfluoroalkyl substances (PFAS) contamination in 10 farms treated with biosolids using a paired control-treatment approach.
Diana Oviedo-Vargas +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Open ChemistryPer- and polyfluoroalkylated substances (PFAS) are a group of anthropogenic chemicals used in a multitude of applications. Nevertheless, PFAS are considered emerging contaminants, posing significant threats to human health as a consequence of their ...
Tzanetou Evangelia N. +3 more
doaj +1 more source
Frontiers in Endocrinology, 2021 Per- or polyfluoroalkyl substances (PFAS), a family of synthetic polyfluorinated compounds, are widely used in consumer products. Ubiquitous exposures to PFAS, in consideration of their persistence, bioaccumulation potential, and toxicities have led to ...
Yun Jeong Lee +5 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Methods for the PFAS analysis proposed in 2022: literature search
, 2022 openRicerca bibliografica su metodi di analisi, essenzialmente cromatografici con HRMS, proposti nel 2022 per determinare i PFAS in diverse ...
PERUZZI, NICOLÒ
core
Impact of the European proposal to restrict PFAS on modern medical technology and treatment options
Current Directions in Biomedical EngineeringFunctionality of state-of-the-art medical devices often depends on high-end materials. Today, a large spectrum of medical devices like heart valves, vascular grafts, sutures or endoscopic devices consist of or incorporate fluoropolymers like ...
Derad Lukas +4 more
doaj +1 more source