Results 31 to 40 of about 27,275 (312)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Mathematical models for predicting the toxicity of micropollutant mixtures in water

Arhiv za Higijenu Rada i Toksikologiju
Water pollution caused by micropollutants has been a global issue for decades, prompting the scientific community and industry professionals to develop new and effective wastewater treatment methods.
Zjačić Josipa Papac, Kušić Hrvoje, Božić Ana Lončarić   +2 more
doaj   +1 more source

Advances in researches on migration and transformation behavior of per- and polyfluoroalkyl substances precursors in the environment

Shuiwen dizhi gongcheng dizhi
Per- and polyfluoroalkyl substances (PFAS) precursors are indirect sources of many PFAS in the environment, widely utilized in various fields such as food packaging, firefighting foams, metal plating, textile coatings, and pesticides.
Xiaohui JIN, Ni YAN
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Comments submitted by Mamme No PFAS for the Public consultation on the draft risk assessment of perfluoroalkyl substances in food

, 2020
The file was submitted by Mamme No PFAS together with their contribution to the Public Consultation launched in February 2020 by the European Food Safety Authority on the draft risk assessment of perfluoroalkyl substances in food.EU; PDF; biocontam@efsa ...
Mamme No PFAS
core   +1 more source

Opportunities and Challenges of Integrated Large-Scale PFAS Modeling: A Case Study for PFAS Modeling at a Watershed Scale

, 2022
The number of poly- and perfluoroalkyl substances (PFAS) and their sources, fates, and avenues of transport is vast. With every new discovery, a new question arises regarding the impact they are having on the environment.
Li, Shu-Guang, Raschke, Anna, Rafiei, Vahid, Nejadhashemi, A. Pouyan, Shabani, Afshin, Fernandez, Nicolas   +5 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

High serum PFAS levels in a population after exposure through drinking water in western Tokyo, Japan and their half-lives estimation

Environmental Health and Preventive Medicine
Background: Per- and polyfluoroalkyl substances (PFAS) have raised significant health concerns. In 2019, drinking water source was changed due to PFAS contamination in the Tama region, Tokyo, Japan.
Zhaoqing Lyu, Kouji H. Harada, Yoshihiko Sugii, Takenori Ueda, Junko Kimura-Kuroda, Shigeharu Nakachi   +5 more
doaj   +1 more source

Targeted analysis and Total Oxidizable Precursor assay of several insecticides for PFAS

Journal of Hazardous Materials Letters, 2022
Targeted analysis for 24 Per- and Polyfluoroalkyl Substances (PFAS) was conducted on 10 insecticide formulations used on a United States Department of Agriculture crop research field.
Steven Lasee, Kaylin McDermett, Naveen Kumar, Jennifer Guelfo, Paxton Payton, Zhao Yang, Todd A. Anderson   +6 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source