Results 41 to 50 of about 27,275 (312)

Contaminants of emerging concern (CECs) in aquatic and terrestrial environments: Sources, impacts, and remediation strategies

Environmental Chemistry and Safety
Contaminants of emerging concern (CECs) refer to various synthetic chemicals—such as pharmaceuticals and personal care products (PPCPs), pesticides, per- and polyfluoroalkyl substances (PFASs), micro/nanoplastics, and nanomaterials—that pose a threat to ...
M. Ky Nguyen, S. Wong Chang, D. Duc Nguyen   +2 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Ubiquitously occurring perfluoroalkyl and polyfluoroalkyl substances: An overview of food and environmental contamination and implications for human health [PDF]

Scripta Medica
Perfluoroalkyl and polyfluoroalkyl substances (PFAS), commonly known as 'forever chemicals' are synthetic, anthropogenic compounds widely used in food packaging, processing equipment and nonstick surfaces.
Jaglan Poonam, Buttar Harpal S., Wilson Douglas W., Telessy Istvan G.   +3 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

A Review of Research Progress on Detection and Screening Techniques for Perfluoroalkyl and Polyfluoroalkyl Substances

Yankuang ceshi
Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals with widespread industrial and commercial applications, ubiquitous in surface water, groundwater, soil, and sediments.
Xuesong LIU, Tao ZHANG, Yanqiu TAO, Yonggao LYU   +3 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Risk Analysis of Per- and Polyfluorinated Alkyl Substances in Leather Products

Pige Kexue Yu Gongcheng
Per- and polyfluoroalkyl substances (PFAS) have been widely employed in leather processing due to their exceptional water- and oil-repellent properties, yet their environmental persistence and bioaccumulative characteristics pose potential threats to ...
Keshuai REN, Qiaoqiao BU, Xinyu DU, Zhenguo YAO, Jiyu LIANG, Jun SANG, Wei LIN   +6 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The impact of surface water-groundwater interactions on the fate and transport of typical PFAS

Shuiwen dizhi gongcheng dizhi
Per- and polyfluoroalkyl substances (PFAS) are a class of ubiquitous and persistent pollutants that pose significant risks to drinking water and human health.
Zhilin GUO, Dongwei ZHAO, Zhanxiang PENG, Xuchen ZHAI   +3 more
doaj   +1 more source