Results 31 to 40 of about 38,799 (355)

Fast PFAS determination in honey by direct probe electrospray ionization tandem mass spectrometry: A health risk assessment insight

Open Chemistry
Per- and polyfluoroalkylated substances (PFAS) are a group of anthropogenic chemicals used in a multitude of applications. Nevertheless, PFAS are considered emerging contaminants, posing significant threats to human health as a consequence of their ...
Tzanetou Evangelia N., Vousaxaki Efstathia, Machera Kyriaki, Kasiotis Konstantinos M.   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Impact of the European proposal to restrict PFAS on modern medical technology and treatment options

Current Directions in Biomedical Engineering
Functionality of state-of-the-art medical devices often depends on high-end materials. Today, a large spectrum of medical devices like heart valves, vascular grafts, sutures or endoscopic devices consist of or incorporate fluoropolymers like ...
Derad Lukas, Thaler Melanie, Wiktor Kevin, Bregulla Rainer, Bader Christian   +4 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Environmental Tobacco Smoke Exposure in Relation to Family Characteristics, Stressors and Chemical Co-Exposures in California Girls. [PDF]

, 2019
Childhood environmental tobacco smoke (ETS) exposure is a risk factor for adverse health outcomes and may disproportionately burden lower socioeconomic status groups, exacerbating health disparities.
Dobraca, Dina, Hiatt, Robert A, Kushi, Lawrence H, Soriano, Jasmine W, Sosnoff, Connie S, Windham, Gayle C   +5 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Mathematical models for predicting the toxicity of micropollutant mixtures in water

Arhiv za Higijenu Rada i Toksikologiju
Water pollution caused by micropollutants has been a global issue for decades, prompting the scientific community and industry professionals to develop new and effective wastewater treatment methods.
Zjačić Josipa Papac, Kušić Hrvoje, Božić Ana Lončarić   +2 more
doaj   +1 more source

Advances in researches on migration and transformation behavior of per- and polyfluoroalkyl substances precursors in the environment

Shuiwen dizhi gongcheng dizhi
Per- and polyfluoroalkyl substances (PFAS) precursors are indirect sources of many PFAS in the environment, widely utilized in various fields such as food packaging, firefighting foams, metal plating, textile coatings, and pesticides.
Xiaohui JIN, Ni YAN
doaj   +1 more source

The context of REDD+ in the Lao People's Democratic Republic: drivers, agents and institutions [PDF]

, 2013
This report explores the drivers (both direct and indirect) of deforestation and forest degradation and discusses the political, economic and social opportunities and constraints that will influence the design and implementation of REDD+ in Laos.
Castella, Jean-Christophe, Lestrelin, Guillaume, Pham Thu Thuy,, Phanvilay, Khamla, Thongmanivong, Sithong, Trockenbrodt, Michael, Vongvisouk, Thoumthone   +6 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source