Virulence in Plasmodium falciparum malaria : mechanisms of PfEMP1-mediated rosetting
, 2013 Malaria is one of the most important infectious diseases in the world and the Plasmodium falciparum parasite is the causative agent of most of the severe cases. The pathogenesis of the disease is complex but sequestration and hence microvascular obstruction is associated with virulence of the parasite. Rosetting, the adhesion of a parasitized red cell (
Davide Angeletti
openalex +2 more sources
Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3 [PDF]
, 2015 Background Mechanisms of acquired protection to malaria in asymptomatic Plasmodium falciparum carriers are only partially understood. Among them, the role plays by the self-reactive antibodies has not been clarified yet.
Becavin, C +8 more
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Antibody responses to surface antigens of Plasmodium falciparum gametocyte-infected erythrocytes and their relation to gametocytaemia. [PDF]
, 2016 : An essential element for continuing transmission of Plasmodium falciparum is the availability of mature gametocytes in human peripheral circulation for uptake by mosquitoes.
Dinko, B +3 more
core +2 more sources
Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding [PDF]
, 2016 Acknowledgements We thank the Red Cross blood bank in Melbourne for human erythrocytes. We thank Svenja Gunther for expression of GBP130 66–196 proteins; Michelle Gazdik and Chris Burns for help in preparing lipids; Lachlan Whitehead (Centre for Dynamic ...
Babon, Jeff J. +14 more
core +1 more source
mBio, 2015 Members of the clonally variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediate adhesion of infected erythrocytes (IEs) to vascular receptors.
Ramesh Subramani +7 more
doaj +1 more source
Longitudinal Assessment of Plasmodium falciparum var Gene Transcription in Naturally Infected Asymptomatic Children in Papua New Guinea [PDF]
, 2017 Sequestration and antigenic variation are essential for Plasmodium falciparum survival in vivo contributing to severe pathologic findings and, also, chronic infection. Both are conferred by P.
Beck, Hans-Peter +4 more
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A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
Memorias do Instituto Oswaldo Cruz, 1992 Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis.
D. J. Kemp +7 more
doaj +1 more source
The structural basis for CD36 binding by the malaria parasite
Nature Communications, 2016 Targeting of the CD36 scavenger receptor by the malaria parasite effector PfEMP1 prevents splenic clearance of infected erythrocytes. Here, the authors propose that diverse PfEMP1 achieve this by binding to a conserved phenylalanine residue in CD36 that ...
Fu-Lien Hsieh +5 more
doaj +1 more source
Prevalence of the protozoan parasite Cryptosporidium on three organic pig farms in Denmark [PDF]
, 2013 Pigs are potential sources of contamination with Cryptosporidium spp., which can lead to infection in humans. Cryptosporidiosis in humans is primarily caused by two species, C. hominis and the zoonotic C. parvum, however, other species including C.
Dalsgaard, Anders +7 more
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