Results 81 to 90 of about 2,727 (170)

Investigating the Host Binding Signature on the Plasmodium falciparum PfEMP1 Protein Family

PLoS Pathogens, 2011
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family plays a central role in antigenic variation and cytoadhesion of P. falciparum infected erythrocytes. PfEMP1 proteins/var genes are classified into three main subfamilies (UpsA, UpsB, and UpsC) that are hypothesized to have different roles in binding and disease.
Janes, Joel, Wang, Christopher, Levin-Edens, Emily, Vigan-Womas, Inès, Guillotte, Micheline, Melcher, Martin, Mercereau-Puijalon, Odile, Smith, Joseph   +7 more
openaire   +5 more sources

The structural basis for CD36 binding by the malaria parasite

Nature Communications, 2016
Targeting of the CD36 scavenger receptor by the malaria parasite effector PfEMP1 prevents splenic clearance of infected erythrocytes. Here, the authors propose that diverse PfEMP1 achieve this by binding to a conserved phenylalanine residue in CD36 that ...
Fu-Lien Hsieh, Louise Turner, Jani Reddy Bolla, Carol V. Robinson, Thomas Lavstsen, Matthew K. Higgins   +5 more
doaj   +1 more source

Sequence variation of PfEMP1-DBLα in association with rosette formation in Plasmodium falciparum isolates causing severe and uncomplicated malaria

Malaria Journal, 2009
Background Rosetting and cytoadherence of Plasmodium falciparum-infected red blood cells have been associated with severity of malaria. ICAM-1 and CD36 are the main host cell receptors, while PfEMP1-DBLα is a major parasite ligand, which can contribute ...
Craig Alister, Kalambaheti Thareerat, Horata Natharinee, Khusmith Srisin   +3 more
doaj   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum.

Cellular microbiology, 2014
The human malaria parasite, Plasmodium falciparum, modifies the red blood cells (RBCs) that it infects by exporting proteins to the host cell. One key virulence protein, P. falciparum Erythrocyte Membrane Protein-1 (PfEMP1), is trafficked to the surface of the infected RBC, where it mediates adhesion to the vascular endothelium.
Paul J, McMillan, Coralie, Millet, Steven, Batinovic, Mauro, Maiorca, Eric, Hanssen, Shannon, Kenny, Rebecca A, Muhle, Martin, Melcher, David A, Fidock, Joseph D, Smith, Matthew W A, Dixon, Leann, Tilley   +11 more
openaire   +2 more sources

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes.

PLoS Pathogens, 2015
Rosetting, the adhesion of Plasmodium falciparum-infected erythrocytes to uninfected erythrocytes, involves clonal variants of the parasite protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) and soluble serum factors. While rosetting is a well-
Liz Stevenson, Erik Laursen, Graeme J Cowan, Betty Bandoh, Lea Barfod, David R Cavanagh, Gregers R Andersen, Lars Hviid   +7 more
doaj   +1 more source

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes.

PLoS Biology, 2018
Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to-or is selected by-this environment
Gerry Q Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh H T Nguyen, Boni F Sebayang, Daniel A Lampah, Jutta Marfurt, Simon A Cobbold, Janavi S Rambhatla, Malcolm J McConville, Stephen J Rogerson, Graham V Brown, Karen P Day, Ric N Price, Nicholas M Anstey, Anthony T Papenfuss, Michael F Duffy   +16 more
doaj   +1 more source

PfEMP1 [PDF]

, 2008
openaire   +1 more source

Genome mapping of malaria resistance genes: the host ligands of PfEMP1

, 2009
Erythrocytes infected by mature forms of the Plasmodium falciparum parasite adhere to other components of the vascular space, a behavior considered critical to the pathogenesis of severe malaria. Adhesion is mediated by the P. falciparum erythrocyte membrane protein 1 (PfEMP1), a highly variant antigen expressed by the parasite and subject to switching
openaire   +2 more sources

Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of <i>Plasmodium falciparum</i> surface proteins into the red blood cell. [PDF]

Elife
Jones D, Belda H, Broncel M, Fuchs G, Anaguano D, Nofal SD, Treeck M.   +6 more
europepmc   +1 more source