Results 61 to 70 of about 2,727 (170)

Ex-vivo cytoadherence phenotypes of Plasmodium falciparum strains from Malian children with hemoglobins A, S, and C. [PDF]

PLoS ONE, 2014
Sickle hemoglobin (Hb) S and HbC may protect against malaria by reducing the expression of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of parasitized red blood cells (RBCs), thereby weakening their cytoadherence to ...
Jeanette T Beaudry, Michael A Krause, Seidina A S Diakite, Michael P Fay, Gyan Joshi, Mahamadou Diakite, Nicholas J White, Rick M Fairhurst   +7 more
doaj   +1 more source

Epistatic Interactions Among Co‐Inherited Malaria‐Protective Red Blood Cell Polymorphisms and Their Effects Across the Infection‐Mortality Spectrum in Endemic Populations: A Systematic Review

Anemia, Volume 2026, Issue 1, 2026.
Background Malaria remains a major global health burden, with red blood cell (RBC) polymorphisms conferring partial protection. However, the epistatic interactions among co‐inherited RBC polymorphisms are poorly understood. We aimed to characterise how epistatic interactions among malaria‐protective RBC polymorphisms modify risk across the infection‐to‐
George Paasi, Ruth Namazzi, Glorias Asiimwe, Grace Ndeezi, Joseph Rujumba, Christine Sekaggya-Wiltshire, Ezekiel Mupere, Ian Guyton Munabi, Sarah Kiguli, Richard Idro, Peter Olupot-Olupot, Duran Canatan   +11 more
wiley   +1 more source

Combined Transcriptome and Proteome Profiling for Role of pfEMP1 in Antimalarial Mechanism of Action of Dihydroartemisinin

Microbiology Spectrum, 2021
Malaria parasites induce morphological and biochemical changes in the membranes of parasite-infected red blood cells (iRBCs) for propagation. Artemisinin combination therapies are the first-line antiplasmodials in countries of endemicity.
Lina Chen, Zhongyuan Zheng, Hui Liu, Xi Wang, Shuiqing Qu, Yuanmin Yang, Shuoqiu Deng, Yu Zhang, Liu Tuo, Yongdan Zhao, Yujie Li   +10 more
doaj   +1 more source

Malaria‐Associated Acute Kidney Injury in a Low‐Endemic Region: A Case Series of Five Imported Plasmodium falciparum Infections

Case Reports in Infectious Diseases, Volume 2026, Issue 1, 2026.
Malaria‐associated acute kidney injury (MAKI) is a formidable and potentially fatal complication of malaria. Early recognition and timely management can significantly reduce morbidity and mortality, particularly in resource‐limited settings. This case series describes five patients with imported Plasmodium falciparum complicated by MAKI who were ...
Daniel P. Mujuni, Abid M. Sadiq, Elisha Luhwago, Datius Mutalemwa, Abel Mwanga, Leanji Leonard, Elifuraha W. Mkwizu, Elichilia R. Shao, Kajiru G. Kilonzo, Mohamed A. Dkhil   +9 more
wiley   +1 more source

Leukocyte and IgM Responses to Immunization with the CIDR1α-PfEMP1 Recombinant Protein in the Wistar Rat

Tropical Medicine and Infectious Disease, 2022
The malaria vaccine is an important strategy for the global malaria elimination program, but the complexity of the Plasmodium antigen is a major hurdle in malaria vaccine development. The cysteine-rich interdomain region 1α (CIDR1α) of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is crucial in malaria pathogenesis, making it a vaccine ...
Erma Sulistyaningsih, Renaldi Wibisono, Rosita Dewi   +2 more
openaire   +3 more sources

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, Volume 6, Issue 5, May 2025.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

Malaria Journal, 2016
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of functional domains called domain cassettes.
Duffy, M, Noviyanti, R, Tsuboi, T, Feng, Z, Trianty, L, Sebayang, B, Takashima, E, Sumardy, F, Lampah, D, Turner, L, Lavstsen, T, Fowkes, F, Siba, P, Rogerson, S, Theander, T, Marfurt, J, Price, R, Anstey, N, Brown, G, Papenfuss, A   +19 more
openaire   +5 more sources

Antithrombotic but not anticoagulant activity of the thrombin‐binding RNA aptamer Apta‐1

British Journal of Pharmacology, Volume 182, Issue 6, Page 1358-1376, March 2025.
Background and Purpose Pharmacological intervention of thrombosis is challenging, requiring a fined tune balance between beneficial antithrombotic effect versus risk of major bleeding complications. In this investigation, we elucidated the antithrombotic capacity of the novel 90‐mer RNA aptamer Apta‐1 and its underlying mechanism of action ...
Luiza Jedlina, Geena Paramel, Svetlana Soboleva, Oldriska Chutna Olin, Marianne Haug, Karin Fransén, Mikael Lindstam, Marta Brewinska‐Olchowik, Katarzyna Piwocka, Magnus Grenegård   +9 more
wiley   +1 more source

The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis research [PDF]

Molecular and Biochemical Parasitology, 2014
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family has a key role in parasite survival, transmission, and virulence. PfEMP1 are exported to the erythrocyte membrane and mediate binding of infected erythrocytes to the endothelial lining of blood vessels.
openaire   +2 more sources

Serum Proteomics of Experimental Malaria‐Associated ARDS Reveals a Regulation of Acute‐Phase Response Proteins

Journal of Immunology Research, Volume 2025, Issue 1, 2025.
Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria‐infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammation and epithelial/endothelial injury pathways have been
Lívia Rosa-Fernandes, Verônica Feijoli Santiago, Yasmin da Silva-Santos, Tissiane Tarosso Lopes, Erika Paula Machado Peixoto, Stefani Aparecida Minchio Rodrigues, Claudio Romero Farias Marinho, Giuseppe Palmisano, Sabrina Epiphanio, Manish Goyal   +9 more
wiley   +1 more source