Results 71 to 80 of about 2,727 (170)

Cytoadhesion of Plasmodium falciparum‐Infected Red Blood Cells Changes the Expression of Cytokine‐, Histone‐ and Antiviral Protein‐Encoding Genes in Brain Endothelial Cells

Molecular Microbiology, Volume 122, Issue 6, Page 948-967, December 2024.
Cytoadhesion of P. falciparum‐infected red blood cells to endothelial cells leads to significant upregulation of genes associated with immune response, nucleosome assembly, NF‐kappa B signaling, and angiogenesis in these cells. Increasing the temperature to 40°C (fever) led to further upregulation of many genes, particularly those involved in cytokine ...
Johannes Allweier, Michael Bartels, Hanifeh Torabi, Maria del Pilar Martinez Tauler, Nahla Galal Metwally, Thomas Roeder, Thomas Gutsmann, Iris Bruchhaus   +7 more
wiley   +1 more source

Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria

BMC Medicine, 2017
Background Expression of group A and the A-like subset of group B Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is associated with severe malaria (SM). The diversity of var sequences combined with the challenges of distinct classification
Estela Shabani, Benjamin Hanisch, Robert O. Opoka, Thomas Lavstsen, Chandy C. John   +4 more
doaj   +1 more source

The complement system: A key player in the host response to infections

European Journal of Immunology, Volume 54, Issue 11, November 2024.
Duality of the complement system during infection: An adequate immune defense clears the infection and restores tissue resilience, whereas a maladaptive response due to complement hyperactivation results in hyperinflammation and tissue injury, as seen in sepsis and pneumonia.
Archana Jayaraman, Sarah Walachowski, Markus Bosmann   +2 more
wiley   +1 more source

Stellabody: A novel hexamer‐promoting mutation for improved IgG potency

Immunological Reviews, Volume 328, Issue 1, Page 438-455, November 2024.
Summary Advances in antibody engineering are being directed at the development of next generation immunotherapeutics with improved potency. Hexamerisation of IgG is a normal physiological aspect of IgG biology and recently described mutations that facilitate this process have a substantial impact upon monoclonal antibody behavior resulting in the ...
Clarissa A. Whitehead, Bruce D. Wines, Anna M. Davies, James M. McDonnell, Halina M. Trist, Sandra E. Esparon, P. Mark Hogarth   +6 more
wiley   +1 more source

Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases

Journal of Extracellular Vesicles, Volume 13, Issue 8, August 2024.
Abstract Parasitic diseases have a significant impact on human and animal health, representing a major hazard to the public and causing economic and health damage worldwide. Extracellular vesicles (EVs) have long been recognized as diagnostic and therapeutic tools but are now also known to be implicated in the natural history of parasitic diseases and ...
Ana Acacia Sá Pinheiro, Ana Claudia Torrecilhas, Bruno Solano de Freitas Souza, Fernanda Ferreira Cruz, Herbert Leonel de Matos Guedes, Tadeu Diniz Ramos, Miqueias Lopes‐Pacheco, Celso Caruso‐Neves, Patricia R. M. Rocco   +8 more
wiley   +1 more source

Plasmodium falciparum Rosetting Epitopes Converge in the SD3-Loop of PfEMP1-DBL1α

PLoS ONE, 2012
La capacité des globules rouges parasités par Plasmodium falciparum (GRp) à former des rosettes avec des globules rouges normaux est liée à la virulence du parasite et les polymorphismes des globules rouges qui affaiblissent le rosage confèrent une protection contre le paludisme grave.
Davide Angeletti, Letusa Albrecht, Karin Blomqvist, María del Pilar Quintana, Tahmina Akhter, Susanna M. Bächle, Alan Sawyer, T. Sandalova, Adnane Achour, Mats Wahlgren, Kirsten Moll   +10 more
openaire   +6 more sources

Natural killer cell antibody‐dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission

Clinical &Translational Immunology, Volume 13, Issue 11, 2024.
Natural killer (NK) cells make important contributions to anti‐malarial immunity through antibody‐dependent cellular cytotoxicity (ADCC), but the role of different components of this pathway in promoting NK cell activation remains unclear. We compared the functions and phenotypes of NK cells from malaria‐exposed and malaria‐naive donors, and then ...
Stephen Tukwasibwe, Savannah Nicole Lewis, Yoweri Taremwa, Kattria van der Ploeg, Kathleen D Press, Maureen Ty, Felistas Namirimu Nankya, Kenneth Musinguzi, Evelyn Nansubuga, Florian Bach, Martin Chamai, Martin Okitwi, Gerald Tumusiime, Annettee Nakimuli, Francesco Colucci, Moses R Kamya, Joaniter I Nankabirwa, Emmanuel Arinaitwe, Bryan Greenhouse, Grant Dorsey, Philip J Rosenthal, Isaac Ssewanyana, Prasanna Jagannathan   +22 more
wiley   +1 more source

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

EMBO Molecular Medicine, 2016
Most severe Plasmodium falciparum infections are experienced by young children. Severe symptoms are precipitated by vascular sequestration of parasites expressing a particular subset of the polymorphic P. falciparum erythrocyte membrane protein 1 (PfEMP1)
Jakob S Jespersen, Christian W Wang, Sixbert I Mkumbaye, Daniel TR Minja, Bent Petersen, Louise Turner, Jens EV Petersen, John PA Lusingu, Thor G Theander, Thomas Lavstsen   +9 more
doaj   +1 more source

A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence

Memorias do Instituto Oswaldo Cruz, 1992
Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis.
D. J. Kemp, J. Thompson, D. A. Barnes, T. Triglia, F. Karamalis, C. Petersen, G. V. Brown, K. P. Day   +7 more
doaj   +1 more source

Plasmodium falciparum-Infected Erythrocyte Knob Density Is Linked to the PfEMP1 Variant Expressed

mBio, 2015
Members of the clonally variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediate adhesion of infected erythrocytes (IEs) to vascular receptors.
Ramesh Subramani, Katharina Quadt, Anine E. Jeppesen, Casper Hempel, Jens Emil Vang Petersen, Tue Hassenkam, Lars Hviid, Lea Barfod   +7 more
doaj   +1 more source