Results 51 to 60 of about 2,727 (170)

Erythrocyte Membrane Protein 3 (EMAP3) Is Exposed on the Surface of the Plasmodium berghei Infected Red Blood Cell

Molecular Microbiology, Volume 125, Issue 3, Page 233-249, March 2026.
Erythrocyte membrane protein 3 (EMAP3) is a novel Plasmodium berghei protein that is trafficked to the outer membrane surface of the infected red blood cell (iRBC). EMAP3 is not critical for parasite growth or sequestration but offers a new scaffold for displaying Plasmodium falciparum proteins on iRBCs.
Sophia Raine C. Hernandez, Ravish Rashpa, Thorey K. Jonsdottir, Martina S. Paoletta, Josy ter Beek, María Rayón Díaz, Jelte M. M. Krol, Severine Chevalley‐Maurel, Takahiro Ishizaki, Ronnie P.‐A. Berntsson, Chris J. Janse, Blandine Franke‐Fayard, Mathieu Brochet, Ellen S. C. Bushell   +13 more
wiley   +1 more source

PfEMP1 expression is reduced on the surface of knoblessPlasmodium falciparuminfected erythrocytes [PDF]

Journal of Cell Science, 2005
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a key virulence factor for this species of human malarial parasite. PfEMP1 is expressed on the surface of infected erythrocytes (IEs) and directly mediates adhesion to a variety of host cells. A number of other parasite-encoded proteins are similarly exported to the IE plasma membrane
Horrocks, P, Pinches, R, Chakravorty, S, Papakrivos, J, Christodoulou, Z, Kyes, SA, Urban, B, Ferguson, D, Newbold, C   +8 more
openaire   +3 more sources

Clathrins Are Involved in the Endocytosis of Host Cytosol in the Malaria Parasite

Traffic, Volume 27, Issue 1, March 2026.
This study characterized clathrin function in hemoglobin uptake from host red blood cells via the malaria parasite's specific endocytosis machinery, cytostome. Clathrin heavy chain, clathrin light chain, and AP‐1 γ subunit were found associated with certain proteins known to be involved in cytostome function, and they were localized at the collars of ...
Jun Miao, Amuza Byaruhanga Lucky, Gang Ning, Xian Xia, Xiaoying Liang, Faiza Siddiqui, Hui Min, Chengqi Wang, Xiaolian Li, Z. Hong Zhou, Liwang Cui   +10 more
wiley   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, Volume 301, Issue 2, Page 122-150, February 2026.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Characterization of a Pfemp1 variant from a P. falciparum field is isolate and the development of anti-Pfemp1 antibodies [PDF]

, 2014
Rosetting (binding of infected erythrocytes to uninfected ones) is a parasite adhesion phenotype thought to be mediated by Plasmodium falciparum membrane protein 1 (PfEMP1). Despite the association between rosetting and severe malaria in Africa, rosette-mediating PfEMP1 variants from African-derived strains are yet to be characterized.
openaire   +1 more source

Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.

PLoS ONE, 2011
BackgroundRosetting is a Plasmodium falciparum virulence factor implicated in the pathogenesis of life-threatening malaria. Rosetting occurs when parasite-derived P.
Ashfaq Ghumra, Pongsak Khunrae, Ricardo Ataide, Ahmed Raza, Stephen J Rogerson, Matthew K Higgins, J Alexandra Rowe   +6 more
doaj   +1 more source

Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1. [PDF]

PLoS ONE, 2015
The ABO blood group antigens are expressed on erythrocytes but also on endothelial cells, platelets and serum proteins. Notably, the ABO blood group of a malaria patient determines the development of the disease given that blood group O reduces the ...
Kirsten Moll, Mia Palmkvist, Junhong Ch'ng, Mpungu Steven Kiwuwa, Mats Wahlgren   +4 more
doaj   +1 more source

Optimized Purification of CIDRα-PfEMP1 Plasmodium falciparum Recombinant Protein with Affinity Chromatography

Jurnal Ilmu Dasar, 2022
Interaction of Cysteine-rich Interdomain Region (CIDR)α-Plasmodium falciparum Erythrocyte Membrane Protein (PfEMP1) and Endothelial Cell Receptors especially CD36 on host cells is main malaria pathogenesis, makes this domain as a malaria vaccine ...
Eqiel Navadz Akthar Alami, Erma Sulistyaningsih, Irawan Fajar Kusuma, Sheilla Rachmania   +3 more
doaj   +1 more source

Artificial intelligence‐powered microscopy: Transforming the landscape of parasitology

Journal of Microscopy, Volume 301, Issue 2, Page 280-329, February 2026.
Abstract Microscopy and image analysis play a vital role in parasitology research; they are critical for identifying parasitic organisms and elucidating their complex life cycles. Despite major advancements in imaging and analysis, several challenges remain. These include the integration of interdisciplinary data; information derived from various model
Mariana De Niz, Sara Silva Pereira, David Kirchenbuechler, Leandro Lemgruber, Constadina Arvanitis   +4 more
wiley   +1 more source

Immune Modulation by Plasmodium yoelii: Insights From Lethal and Non‐Lethal Strains

Parasite Immunology, Volume 48, Issue 1, January 2026.
ABSTRACT Malaria pathogenesis is driven by intricate host–parasite interactions that determine immune balance and clinical outcome. The Plasmodium yoelii model, particularly its lethal (17XL) and non‐lethal (17XNL) strains, provides a robust framework to investigate these dynamics.
Sharoen Yu Ming Lim
wiley   +1 more source