Results 41 to 50 of about 2,727 (170)

MOLECULAR-GENETIC MECHANISMS OF PLASMODIUM FALCIPARUM VIRULENCE AND TROPICAL MALARIA PATHOGENESIS

Журнал инфектологии, 2018
There is introduced the analysis of molecular-genetic mechanisms of tropical malaria pathogenesis and P. falciparum virulence. It is shown, that pathogenesis of tropical malaria is associated with the properties of red blood cells membrane surface (RBCs ...
A. N. Uskov, A. I. Soloviev, V. Yu. Kravtsov, R. V. Gudkov, E. V. Kolomoets, A. E. Levkovskiy   +5 more
doaj   +1 more source

Total Leukocyte Count in Rattus norvegicus after Duffy Binding-Like 2β-Plasmodium falciparum Erythrocyte Membrane Protein 1 Recombinant Protein Injection: The way to a Peptide-based Malaria Vaccine Development

Biomolecular and Health Science Journal, 2022
Introduction: Severe malaria caused by Plasmodium falciparum is mediated by the P. falciparum erythrocyte membrane protein 1 (PfEMP1). It has a DBL2β domain that specifically binds to the intercellular adhesion molecule-1 (ICAM-1) receptor that lies in ...
Dwi Ari Santi Putri, Erma Sulistyaningsih, Irawan Fajar Kusuma, Rosita Dewi   +3 more
doaj   +1 more source

Evaluation of Kidney Proximal Tubule Following Immunization with Plasmodium falciparum CIDR1α-PfEMP1 Recombinant Protein in Rats

Majalah Kedokteran Bandung
Malaria vaccines are continuously explored as an approach to eradicate malaria. The cysteine-rich interdomain region 1α-Plasmodium falciparum erythrocyte membrane protein 1 (CIDR1α-PfEMP1) is an antigenic protein that can bind to the endothelial protein ...
Rosita Dewi, Erma Sulistyaningsih, Irawan Fajar Kusuma, Sheilla Rachmania, Nafisah Hani Asyifah Rahma   +4 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Regulation of PfEMP1–VAR2CSA translation by a Plasmodium translation-enhancing factor

Nature Microbiology, 2017
Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate A (CSA) through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed by an upstream open reading frame. In this study, we report that the P.
Sherwin Chan, Alejandra Frasch, Chandra Sekhar Mandava, Jun-Hong Ch'ng, Maria del Pilar Quintana, Mattias Vesterlund, Mehdi Ghorbal, Nicolas Joannin, Oscar Franzén, Jose-Juan Lopez-Rubio, Sonia Barbieri, Antonio Lanzavecchia, Suparna Sanyal, Mats Wahlgren   +13 more
openaire   +4 more sources

Sensitive real-time PCR detection of Plasmodium falciparum parasites in whole blood by erythrocyte membrane protein 1 gene amplification

Malaria Journal, 2019
Background Malaria remains a global public health problem responsible for 445,000 deaths in 2016. While microscopy remains the mainstay of malaria diagnosis, highly sensitive molecular methods for detection of low-grade sub-microscopic infections are ...
Bryan Grabias, Edward Essuman, Isabella A. Quakyi, Sanjai Kumar   +3 more
doaj   +1 more source

A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes

Malaria Journal, 2008
Background The insertion of parasite antigens into the host erythrocyte membrane and the structure and distribution of Plasmodium falciparum adhesion receptors on that membrane are poorly understood.
Arnot David E, Theander Thor G, Turner Louise, Joergensen Louise, Jensen Anja TR, Salanti Ali, Sowa Kordai M, Bengtsson Dominique   +7 more
doaj   +1 more source

Knobs, Adhesion, and Severe Falciparum Malaria

Tropical Medicine and Infectious Disease, 2023
Plasmodium falciparum can cause a severe disease with high mortality. A major factor contributing to the increased virulence of P. falciparum, as compared to other human malarial parasites, is the sequestration of infected erythrocytes in the capillary ...
Mark F. Wiser
doaj   +1 more source

The Role of Haemoglobin Variants and Red Blood Cell Polymorphisms in Asymptomatic Malaria: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Human phenotypes, particularly blood group polymorphisms (ABO) and haemoglobin variants (HbAA and HbAS), have been widely studied in relation to clinical malaria. However, their role in asymptomatic malaria remains underexplored. This study therefore, investigated the association of these phenotypic variants with the burden
Enoch Aninagyei, Comfort Addo Boatey, John Gameli Deku, Adjoa Agyemang Boakye, Ebenezer Nyarkotey, Gifty Larbi, Desmond Omane Acheampong   +6 more
wiley   +1 more source

PfEMP1 as a target of human immunity and a vaccine candidate against malaria

Expert Review of Vaccines, 2013
The development of an effective malaria vaccine is a major priority for malaria control and elimination.
James G, Beeson, Jo-Anne, Chan, Freya J I, Fowkes   +2 more
openaire   +2 more sources