Results 31 to 40 of about 2,727 (170)

Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells. [PDF]

PLoS ONE, 2007
BACKGROUND: Host innate immunity contributes to malaria clinical outcome by providing protective inflammatory cytokines such as interferon-gamma, and by shaping the adaptive immune response.
Myriam Baratin, Sophie Roetynck, Bruno Pouvelle, Céline Lemmers, Nicola K Viebig, Sofia Johansson, Philippe Bierling, Artur Scherf, Jürg Gysin, Eric Vivier, Sophie Ugolini   +10 more
doaj   +1 more source

A Systematic Targeted Genetic Screen Identifies Proteins Involved in Cytoadherence of the Malaria Parasite P. falciparum. [PDF]

Mol Microbiol
In silico workflow for selection of genes targeted in this study. We have identified a number of proteins involved in host cell modification by malaria parasites. Furthermore, we highlight a number of genes that appear to be essential for blood‐stage survival of these parasites.
Küster N, Roling L, Ouayoue A, Steeg K, Przyborski JM.   +4 more
europepmc   +2 more sources

ICAM-1-binding Plasmodium falciparum erythrocyte membrane protein 1 variants elicits opsonic-phagocytosis IgG responses in Beninese children

Scientific Reports, 2022
Members of the highly polymorphic Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family expressed on the surface of infected erythrocytes (IEs) are important virulence factors, which mediate vascular adhesion of IEs via endothelial host ...
Jennifer Suurbaar, Azizath Moussiliou, Rachida Tahar, Rebecca W. Olsen, Yvonne Adams, Nanna Dalgaard, Eric K. Baafour, Selorme Adukpo, Lars Hviid, Kwadwo A. Kusi, Jules Alao, Michael F. Ofori, Nicaise T. Ndam, Anja R. Jensen   +13 more
doaj   +1 more source

Erythrocyte miRNA-92a-3p interactions with PfEMP1 as determinants of clinical malaria

Functional & Integrative Genomics, 2023
AbstractBased on the recently added high throughput analysis data on small noncoding RNAs in modulating disease pathophysiology of malaria, we performed an integrative computational analysis for exploring the role of human-host erythrocytic microRNAs (miRNAs) and their influence on parasite survival and host homeostasis.
Prabhu, Sowmya R., Ware, Akshay Pramod, Umakanth, Shashikiran, Hande, Manjunath, Mahabala, Chakrapani, Saadi, Abdul Vahab, Satyamoorthy, Kapaettu   +6 more
openaire   +2 more sources

High throughput functional assays of the variant antigen PfEMP1 reveal a single domain in the 3D7 Plasmodium falciparum genome that binds ICAM1 with high affinity and is targeted by naturally acquired neutralizing antibodies. [PDF]

PLoS Pathogens, 2009
Plasmodium falciparum-infected erythrocytes bind endothelial receptors to sequester in vascular beds, and binding to ICAM1 has been implicated in cerebral malaria. Binding to ICAM1 may be mediated by the variant surface antigen family PfEMP1: for example,
Andrew V Oleinikov, Emily Amos, Isaac Tyler Frye, Eddie Rossnagle, Theonest K Mutabingwa, Michal Fried, Patrick E Duffy   +6 more
doaj   +1 more source

Clag9 is not essential for PfEMP1 surface expression in non-cytoadherent Plasmodium falciparum parasites with a chromosome 9 deletion. [PDF]

PLoS ONE, 2011
BACKGROUND: The expression of the clonally variant virulence factor PfEMP1 mediates the sequestration of Plasmodium falciparum infected erythrocytes in the host vasculature and contributes to chronic infection.
Adéla Nacer, Emeric Roux, Sébastien Pomel, Christine Scheidig-Benatar, Hiroshi Sakamoto, Frank Lafont, Artur Scherf, Denise Mattei   +7 more
doaj   +1 more source

Immunity to Severe Malaria: PfEMP1 Tags Tell a Tale [PDF]

Cell Host & Microbe, 2019
PfEMP1 is the major surface antigen of P. falciparum-infected erythrocytes, mediates endothelial adhesion, and displays extreme sequence diversity that underpins antigenic variation. In this issue of Cell Host & Microbe, Tessema et al. (2019) find that antibodies in sera from a pediatric cohort that bind a discrete PfEMP1 subset associate with ...
openaire   +2 more sources

Convalescent Plasmodium falciparum-specific seroreactivity does not correlate with paediatric malaria severity or Plasmodium antigen exposure

Malaria Journal, 2018
Background Antibody immunity is thought to be essential to prevent severe Plasmodium falciparum infection, but the exact correlates of protection are unknown.
Anne Kessler, Joseph J. Campo, Visopo Harawa, Wilson L. Mandala, Stephen J. Rogerson, Wenzhu B. Mowrey, Karl B. Seydel, Kami Kim   +7 more
doaj   +1 more source

Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions.

PLoS Pathogens, 2017
Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) and Knob-associated Histidine-rich Protein (KAHRP) are directly linked to malaria pathology. PfEMP1 and KAHRP cluster on protrusions (knobs) on the P.
Erin E Cutts, Niklas Laasch, Dirk M Reiter, Raphael Trenker, Leanne M Slater, Phillip J Stansfeld, Ioannis Vakonakis   +6 more
doaj   +1 more source

Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1. [PDF]

PLoS Pathogens, 2010
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to malaria.
Louise Joergensen, Dominique C Bengtsson, Anja Bengtsson, Elena Ronander, Sanne S Berger, Louise Turner, Michael B Dalgaard, Gerald K K Cham, Michala E Victor, Thomas Lavstsen, Thor G Theander, David E Arnot, Anja T R Jensen   +12 more
doaj   +1 more source