Results 11 to 20 of about 2,727 (170)

The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs [PDF]

Malaria Journal, 2010
Background Infected humans make protective antibody responses to the PfEMP1 adhesion antigens exported by Plasmodium falciparum parasites to the erythrocyte membrane, but little is known about the kinetics of this antibody-receptor binding reaction or ...
Arnot David E, Hviid Lars, Hassenkam Tue, Theander Thor G, Barfod Lea, Dobrilovic Tina, Salanti Ali, Joergensen Lars M   +7 more
doaj   +5 more sources

Breaking the bind: PfEMP1-specific antibodies in cerebral malaria. [PDF]

Front Immunol
Antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) on infected erythrocytes (IEs) play a central role in naturally acquired protection against cerebral malaria (CM), yet the determinants of effective humoral immunity remain incompletely defined.
Banda JP, Walker IS, Nyirenda T, Aitken EH, Rogerson SJ.   +4 more
europepmc   +3 more sources

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it [PDF]

Immunological Reviews, 2019
AbstractMalaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites have the unique capacity to infect and replicate within host erythrocytes.
Anja Ramstedt Jensen, Yvonne Adams, Lars Hviid   +2 more
openaire   +4 more sources

PfEMP1’s Magical Embrace of EPCR [PDF]

Cell Host & Microbe, 2015
Since discovering PfEMP1 virulence proteins in Plasmodium falciparum, malariologists have struggled to reconcile their limitless sequence diversity with their binding to relatively few host receptors. In this issue of Cell Host & Microbe, Lau et al.
openaire   +3 more sources

Differential PfEMP1 Expression Is Associated with Cerebral Malaria Pathology [PDF]

PLoS Pathogens, 2014
Plasmodium falciparum est unique parmi les paludisme humains dans sa capacité à séquestrer dans les veinules post-capillaires des organes hôtes. Les principaux antigènes variants impliqués sont la protéine membranaire 1 des érythrocytes de P. falciparum (PfEMP1), qui peut être divisée en trois groupes principaux (A-C).
Dumizulu Tembo, Benjamin N Nyoni, Rekah V. Murikoli, Mavuto Mukaka, Danny A. Milner, Matthew Berriman, Stephen J. Rogerson, Terrie E. Taylor, Malcolm E. Molyneux, Wilson L. Mandala, Alister G. Craig, Jacqui Montgomery   +11 more
openaire   +7 more sources

PfEMP1, polymorphism and pathogenesis

Annals of Tropical Medicine And Parasitology, 1997
The virulence of Plasmodium falciparum relative to the other species of malarial parasite which infect humans is thought to be due to this parasite's ability to adhere to endothelial cells lining small blood vessels and, in some cases, to its ability to form rosettes with uninfected erythrocytes.
Newbold, C, Craig, A, Kyes, S, Berendt, A, Snow, R, Peshu, N, Marsh, K   +6 more
openaire   +3 more sources

Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquer.

PLoS Computational Biology, 2010
The var gene encoded hyper-variable Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediates cytoadhesion of infected erythrocytes to human endothelium.
Thomas S Rask, Daniel A Hansen, Thor G Theander, Anders Gorm Pedersen, Thomas Lavstsen   +4 more
doaj   +1 more source

The Expression of The PfEMP1-DBL2β Recombinant Protein of Plasmodium falciparum Welch, 1897 Isolated From Indonesia

Jurnal Ilmu Dasar, 2020
The binding of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) to Intracellular Adhesion Molecule-1 (ICAM-1) is a major pathological mechanism in severe malaria including cerebral malaria. The binding is mediated by PfEMP1-DBL2β domain. The
Fathul Hidayatul Hasanah, Erma Sulistyaningsih, Widhi Dyah Sawitri   +2 more
doaj   +1 more source

THE CIDR1α-PfEMP1 SEQUENCE FROM INDONESIAN PLASMODIUM FALCIPARUM AND ITS POTENTIAL ASSOCIATION WITH THE CEREBRAL OUTCOME

Malang Neurology Journal, 2021
Background: Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is an important protein responsible for the pathogenesis of severe malaria, including cerebral malaria. The protein is highly diverse.
Erma Sulistyaningsih, Yunita Armiyanti, Rosita Dewi   +2 more
doaj   +1 more source

Role of Plasmodium falciparum Protein GEXP07 in Maurer’s Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking

mBio, 2020
The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to the surface of infected red blood cells (RBCs) via membranous organelles, known as the Maurer’s clefts.
Emma McHugh, Olivia M. S. Carmo, Adam Blanch, Oliver Looker, Boyin Liu, Snigdha Tiash, Dean Andrew, Steven Batinovic, Andy J. Y. Low, Hyun-Jung Cho, Paul McMillan, Leann Tilley, Matthew W. A. Dixon   +12 more
doaj   +1 more source