Results 1 to 10 of about 2,658 (113)

A system for functional studies of the major virulence factor of malaria parasites [PDF]

eLife
PfEMP1 is a variable antigen displayed on erythrocytes infected with the malaria parasite Plasmodium falciparum. PfEMP1 mediates binding of the infected cell to the endothelium of blood vessels, a cause of severe malaria.
Jakob Cronshagen, Johannes Allweier, Joëlle Paolo Mesén-Ramírez, Jan Stäcker, Anna Viktoria Vaaben, Gala Ramón-Zamorano, Isabel Naranjo-Prado, Max Graser, Patricia López-Barona, Susann Ofori, Pascal WTC Jansen, Joëlle Hornebeck, Florian Kieferle, Agnes Murk, Elicia Martin, Carolina Castro-Peña, Richárd Bártfai, Thomas Lavstsen, Iris Bruchhaus, Tobias Spielmann   +19 more
doaj   +2 more sources

Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG

Frontiers in Immunology, 2019
Members of the PfEMP1 protein family are expressed on the surface of P. falciparum-infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are important targets of acquired immunity.
Mads Delbó Larsen, Maria Del Pilar Quintana, Sisse Bolm Ditlev   +2 more
exaly   +3 more sources

Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype. [PDF]

PLoS Pathogens
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding of infected erythrocytes to human cells and plays a key role in parasite immune evasion and malaria
Florence E McLean, Brian R Omondi, Nouhoum Diallo, Stanley Otoboh, Carolyne Kifude, Abdirahman I Abdi, Rivka Lim, Thomas D Otto, Ashfaq Ghumra, J Alexandra Rowe   +9 more
doaj   +2 more sources

IgG and IgM responses to PfEMP1 domains associated with semi-immunity to clinical malaria in Burkinabe children under five [PDF]

Frontiers in Immunology
BackgroundMalaria remains a major global health burden, with children under five years in sub-Saharan Africa disproportionately affected. While immunity develops with repeated exposure, the specific correlates of protection in early childhood are not ...
Benedicta O. Dankyi, Takaaki Yuguchi, Rattanaporn Rojrung, Hikaru Nagaoka, Bernard N. Kanoi, Alfred B. Tiono, Issa Nebie, Alphonse Ouedraogo, Keiko Tanaka, Yoshihiro Miyake, Kazutoyo Miura, Jetsumon Sattabongkot, Sodiomon B. Sirima, Takafumi Tsuboi, Eizo Takashima   +14 more
doaj   +2 more sources

A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection

Cell Reports, 2018
Summary: Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and transmission of the malaria parasite Plasmodium falciparum during blood stage infection.
Shruthi S Vembar, Sebastian Baumgarten, Julien Guizetti   +2 more
exaly   +3 more sources

A monoclonal antibody selectively recognizing PfEMP1 proteins associated with cerebral malaria [PDF]

Scientific Reports
The frequently fatal outcome of cerebral malaria has been linked to the adhesion and accumulation in the cerebral microvasculature of infected erythrocytes (IEs), which express a particular type of Plasmodium falciparum erythrocyte membrane protein 1 ...
Nanna Dalgaard, Rebecca W. Olsen, Yvonne Adams, Blanca L. Mendez, Jonas J. Rudbaek, Sofie Amalie G. Bisholm, Azizath Mousiliou, Melanie R. Walker, Lars Hviid, Rachida Tahar, Nicaise T. Ndam, Lea Barfod, Anja R. Jensen   +12 more
doaj   +2 more sources

Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria [PDF]

Nature Communications
Protective immunity to malaria depends on acquisition of parasite-specific antibodies, with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) being one of the most important target antigens.
Mary Lopez-Perez, Zakaria Seidu, Mads Delbo Larsen, Wenjun Wang, Jan Nouta, Manfred Wuhrer, Gestur Vidarsson, Michael F. Ofori, Lars Hviid   +8 more
doaj   +2 more sources

Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1. [PDF]

PLoS ONE, 2013
Members of the Plasmodium falciparum Erythrocyte Membrane protein 1 (PfEMP1) family expressed on the surface of malaria-infected erythrocytes mediate binding of the parasite to different receptors on the vascular lining.
Sanne S Berger, Louise Turner, Christian W Wang, Jens E V Petersen, Maria Kraft, John P A Lusingu, Bruno Mmbando, Andrea M Marquard, Dominique B A C Bengtsson, Lars Hviid, Morten A Nielsen, Thor G Theander, Thomas Lavstsen   +12 more
doaj   +1 more source

In Vitro Variant Surface Antigen Expression in Plasmodium falciparum Parasites from a Semi-Immune Individual Is Not Correlated with Var Gene Transcription. [PDF]

PLoS ONE, 2016
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is considered to be the main variant surface antigen (VSA) of Plasmodium falciparum and is mainly localized on electron-dense knobs in the membrane of the infected erythrocyte.
Ellen Inga Bruske, Sandra Dimonte, Corinna Enderes, Serena Tschan, Matthias Flötenmeyer, Iris Koch, Jürgen Berger, Peter Kremsner, Matthias Frank   +8 more
doaj   +1 more source

Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation

Scientific Reports, 2021
Plasmodium falciparum erythrocyte membrane protein-1s (PfEMP1s), diverse malaria proteins expressed on the infected erythrocyte surface, play an important role in pathogenesis, mediating adhesion to host vascular endothelium. Antibodies to particular non-
Noah T. Ventimiglia, Emily M. Stucke, Drissa Coulibaly, Andrea A. Berry, Kirsten E. Lyke, Matthew B. Laurens, Jason A. Bailey, Matthew Adams, Amadou Niangaly, Abdoulaye K. Kone, Shannon Takala-Harrison, Bourema Kouriba, Ogobara K. Doumbo, Phillip L. Felgner, Christopher V. Plowe, Mahamadou A. Thera, Mark A. Travassos   +16 more
doaj   +1 more source