Results 21 to 30 of about 2,727 (170)

Default Pathway of var2csa switching and translational repression in Plasmodium falciparum. [PDF]

PLoS ONE, 2008
Antigenic variation is a subtle process of fundamental importance to the survival of a microbial pathogen. In Plasmodium falciparum malaria, PfEMP1 is the major variable antigen and adhesin expressed at the surface of the infected erythrocyte, which is ...
Bobo W Mok, Ulf Ribacke, Niloofar Rasti, Fred Kironde, Qijun Chen, Peter Nilsson, Mats Wahlgren   +6 more
doaj   +1 more source

From genomic to LC-MS/MS evidence: Analysis of PfEMP1 in Benin malaria cases.

PLoS ONE, 2019
BACKGROUND:PfEMP1 is the major protein from parasitic origin involved in the pathophysiology of severe malaria, and PfEMP1 domain subtypes are associated with the infection outcome.
Claire Kamaliddin, David Rombaut, Emilie Guillochon, Jade Royo, Sem Ezinmegnon, Gino Agbota, Stéphanie Huguet, Sayeh Guemouri, Céline Peirera, Romain Coppée, Cédric Broussard, Jules M Alao, Agnès Aubouy, François Guillonneau, Philippe Deloron, Gwladys I Bertin   +15 more
doaj   +1 more source

The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure. [PDF]

PLoS Pathogens, 2008
Plasmodium falciparum malaria parasites, living in red blood cells, express proteins of the erythrocyte membrane protein-1 (PfEMP1) family on the red blood cell surface.
Michael M Klein, Apostolos G Gittis, Hua-Poo Su, Morris O Makobongo, Jaime M Moore, Sanjay Singh, Louis H Miller, David N Garboczi   +7 more
doaj   +1 more source

Common virulence gene expression in adult first-time infected malaria patients and severe cases

eLife, 2021
Sequestration of Plasmodium falciparum(P. falciparum)-infected erythrocytes to host endothelium through the parasite-derived P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion proteins is central to the development of malaria pathogenesis ...
J Stephan Wichers, Gerry Tonkin-Hill, Thorsten Thye, Ralf Krumkamp, Benno Kreuels, Jan Strauss, Heidrun von Thien, Judith AM Scholz, Helle Smedegaard Hansson, Rasmus Weisel Jensen, Louise Turner, Freia-Raphaella Lorenz, Anna Schöllhorn, Iris Bruchhaus, Egbert Tannich, Rolf Fendel, Thomas D Otto, Thomas Lavstsen, Tim W Gilberger, Michael F Duffy, Anna Bachmann   +20 more
doaj   +1 more source

Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1

Cell Reports, 2016
Plasmodium falciparum virulence is associated with sequestration of infected erythrocytes. Microvascular binding mediated by PfEMP1 in complex with non-immune immunoglobulin M (IgM) is common among parasites that cause both severe childhood malaria and ...
Reetesh Raj Akhouri, Suchi Goel, Hirotoshi Furusho, Ulf Skoglund, Mats Wahlgren   +4 more
doaj   +1 more source

T-cell responses to the DBLα-tag, a short semi-conserved region of the Plasmodium falciparum membrane erythrocyte protein 1.

PLoS ONE, 2012
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a variant surface antigen expressed on mature forms of infected erythrocytes. It is considered an important target of naturally acquired immunity.
Evelyn N Gitau, James Tuju, Liz Stevenson, Eva Kimani, Henry Karanja, Kevin Marsh, Peter C Bull, Britta C Urban   +7 more
doaj   +1 more source

Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers. [PDF]

PLoS ONE, 2011
Antibodies to polymorphic antigens expressed during the parasites erythrocytic stages are important mediators of protective immunity against P. falciparum malaria.
Louise Turner, Christian W Wang, Thomas Lavstsen, Steven B Mwakalinga, Robert W Sauerwein, Cornelus C Hermsen, Thor G Theander   +6 more
doaj   +1 more source

Interaction Analysis of a Plasmodium falciparum PHISTa-like Protein and PfEMP1 Proteins [PDF]

Frontiers in Microbiology, 2020
Plasmodium falciparum extensively remodels host cells by translocating numerous proteins into the cytoplasm of red blood cells (RBCs) after invasion. Among these exported proteins, members of the Plasmodium helical interspersed subtelomeric (PHIST) family are crucial for host cell remodeling and host-parasite interactions, and thereby contribute to ...
Baoling Yang, Baoling Yang, Baoling Yang, Xiaofeng Wang, Ning Jiang, Ning Jiang, Xiaoyu Sang, Xiaoyu Sang, Ying Feng, Ying Feng, Ran Chen, Ran Chen, Xinyi Wang, Xinyi Wang, Qijun Chen, Qijun Chen   +15 more
openaire   +3 more sources

Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites.

PLoS Pathogens, 2012
Sequence diversity in pathogen antigens is an obstacle to the development of interventions against many infectious diseases. In malaria caused by Plasmodium falciparum, the PfEMP1 family of variant surface antigens encoded by var genes are adhesion ...
Ashfaq Ghumra, Jean-Philippe Semblat, Ricardo Ataide, Carolyne Kifude, Yvonne Adams, Antoine Claessens, Damian N Anong, Peter C Bull, Clare Fennell, Monica Arman, Alfred Amambua-Ngwa, Michael Walther, David J Conway, Lalla Kassambara, Ogobara K Doumbo, Ahmed Raza, J Alexandra Rowe   +16 more
doaj   +1 more source

Serologic responses to the PfEMP1 DBL-CIDR head structure may be a better indicator of malaria exposure than those to the DBL-α tag

Malaria Journal, 2019
Background Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to
Emily M. Stucke, Amadou Niangaly, Andrea A. Berry, Jason A. Bailey, Drissa Coulibaly, Amed Ouattara, Kirsten E. Lyke, Matthew B. Laurens, Antoine Dara, Matthew Adams, Jozelyn Pablo, Algis Jasinskas, Rie Nakajima, Albert E. Zhou, Sonia Agrawal, DeAnna J. Friedman-Klabanoff, Shannon Takala-Harrison, Bourema Kouriba, Abdoulaye K. Kone, J. Alexandra Rowe, Ogobara K. Doumbo, Philip L. Felgner, Mahamadou A. Thera, Christopher V. Plowe, Mark A. Travassos   +24 more
doaj   +1 more source