Results 111 to 120 of about 6,004 (229)

Single molecule and multiple bond characterization of catch bond associated cytoadhesion in malaria [PDF]

, 2017
The adhesion of malaria infected red blood cells (iRBCs) to host endothelial receptors in the microvasculature, or cytoadhesion, is associated with severe disease pathology such as multiple organ failure and cerebral malaria.
Cao, Jianshu, Lim, Chwee-Teck, Lim, Ying Bena, Thingna, Juzar   +3 more
core   +1 more source

Sequence variation of PfEMP1-DBLα in association with rosette formation in Plasmodium falciparum isolates causing severe and uncomplicated malaria

Malaria Journal, 2009
Background Rosetting and cytoadherence of Plasmodium falciparum-infected red blood cells have been associated with severity of malaria. ICAM-1 and CD36 are the main host cell receptors, while PfEMP1-DBLα is a major parasite ligand, which can contribute ...
Craig Alister, Kalambaheti Thareerat, Horata Natharinee, Khusmith Srisin   +3 more
doaj   +1 more source

Analysis of Structure and Function of the Giant Protein Pf332 in Plasmodium falciparum [PDF]

, 2010
Virulence of Plasmodium falciparum, the most lethal parasitic disease in humans, results in part from adhesiveness and increased rigidity of infected erythrocytes.
Beeson, James, Brown, Monica, Cowman, Alan F., Hodder, Anthony N, Hommel, Mirja, Maier, Alexander G, Pantic, Ivan, Puig-de-Morales-Marinkovic, Marina, Rug, Melanie, Smith, Brian, Triglia, Tony   +10 more
core   +1 more source

The Gates Malaria Partnership: a consortium approach to malaria research and capacity development.

, 2012
Recently, there has been a major increase in financial support for malaria control. Most of these funds have, appropriately, been spent on the tools needed for effective prevention and treatment of malaria such as insecticide-treated bed nets, indoor ...
Bhasin, Amit, Greenwood, Brian, Targett, Geoffrey   +2 more
core   +1 more source

Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)

PLOS Pathogens, 2019
Naturally acquired clinical immunity to Plasmodium falciparum is partly mediated by antibodies directed at parasite-derived antigens expressed on the surface of red blood cells which mediate disease and are extremely diverse. Unlike children, adults recognize a broad range of variant surface antigens (VSAs) and are protected from severe disease. Though
Tuju, J, Mackinnon, M, Abdi, A, Karanja, H, Musyoki, J, Warimwe, G, Gitau, E, Marsh, K, Bull, P, Urban, B   +9 more
openaire   +4 more sources

Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria [PDF]

, 2014
Clinton K. Lau, Louise Turner, Jakob S. Jespersen, E.D. Lowe, Bent Petersen, Christian W. Wang, Jens E. V. Petersen, John Lusingu, Thor G. Theander, Thomas Lavstsen, Matthew K. Higgins   +10 more
openalex   +1 more source

Immune selection and within-host competition can structure the repertoire of variant surface antigens in Plasmodium falciparum--a mathematical model.

PLoS ONE, 2010
BackgroundThe evolutionary mechanisms structuring the expression pattern of variant surface antigen (VSA) families that allow pathogens to evade immune responses and establish chronic and repeated infections pose major challenges to theoretical research.
Sander P van Noort, Marta C Nunes, Gareth D Weedall, Lars Hviid, M Gabriela M Gomes   +4 more
doaj   +1 more source

Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1 [PDF]

, 2023
Sai Sundar Rajan Raghavan, Louise Turner, Rasmus W. Jensen, Nicolai Tidemand Johansen, Daniel Skjold Jensen, Pontus Gourdon, Jinqiu Zhang, Yong Wang, Thor G. Theander, Kaituo Wang, Thomas Lavstsen   +10 more
openalex   +1 more source

New Inhibitors Predicted for Plasmodium Falciparum Erythrocyte Membrane Protein1 (PfEMP1)

TSF Journal of Biology
Malaria is a mosquito-borne disease caused by several Plasmodium species. It poses a substantial global health burden, infecting approximately 300 million individuals and resulting in over one million mortalities annually. The primary mode of infection occurs through the transmission of sporozoites by infected mosquitoes during blood feeding ...
Abdul Wahab, Adnan Shehzad, Bibi Ayesha, Hamid Ur Rahman   +3 more
openaire   +1 more source

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes.

PLoS Biology, 2018
Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple selection pressures. The host environment changes dramatically in severe malaria, but the extent to which the parasite responds to-or is selected by-this environment
Gerry Q Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh H T Nguyen, Boni F Sebayang, Daniel A Lampah, Jutta Marfurt, Simon A Cobbold, Janavi S Rambhatla, Malcolm J McConville, Stephen J Rogerson, Graham V Brown, Karen P Day, Ric N Price, Nicholas M Anstey, Anthony T Papenfuss, Michael F Duffy   +16 more
doaj   +1 more source