Results 131 to 140 of about 2,727 (170)

Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell

Jones D, Belda H, Broncel M, Fuchs G, Anaguano D, Nofal SD, Treeck M.   +6 more
europepmc   +1 more source

Evasive mechanisms of human VSG and PfEMP1 antigens with link to Vaccine scenario: a review. [PDF]

J Parasit Dis
Obi OA, Obiezue RN, Eze D, Adebote DA.
europepmc   +1 more source

Children with hemoglobin C or S trait have low serologic responses to a subset of malaria variant surface antigens. [PDF]

J Infect
Bailey RD, Lawton JG, Niangaly A, Stucke EM, Bailey JA, Berry AA, Ouattara A, Coulibaly D, Lyke KE, Laurens MB, Zhou AE, Pablo J, Jasinskas A, Nakajima R, Adams M, Takala-Harrison S, Kouriba B, Kone AK, Guindo A, Rowe JA, Diallo DA, Doumbo OK, Felgner PL, Plowe CV, Thera MA, Travassos MA.   +25 more
europepmc   +1 more source

Plasmodium falciparum expresses fewer var genes at lower levels during asymptomatic dry season infections than clinical malaria cases

Ceesay S, Kampmann M, Votborg-Novél L, Hansson HS, Jensen RW, Carrasquilla M, Cisse H, Turner L, Dabbas U, Ntalla C, Bandermann S, Doumbo S, Doumtabe D, Ongoiba A, Kayentao K, Traore B, Crompton PD, Lavstsen T, Portugal S.   +18 more
europepmc   +1 more source

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var genes, PfEMP1 and the human host

Molecular and Biochemical Parasitology, 2004
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important virulence factor encoded by a family of roughly 60 var genes and is used by the parasite to interact with the human host. The parasite regularly exchanges the expressed var gene generating antigenic variation of the infected RBCs (pRBC) surface which is crucial for successful
Qijun Chen
exaly   +3 more sources

Extraction and Immunoprecipitation of VAR2CSA, the PfEMP1 Associated with Placental Malaria

Methods in Molecular Biology, 2022
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a key virulence factor for this human malaria parasite. During pregnancy, VAR2CSA is the only PfEMP1 variant expressed on the surface of infected erythrocytes that mediates adhesion to placenta cells and causes severe pregnancy outcomes.In this chapter, we present an optimized ...
Benoit Gamain, Dominique Dorin-Semblat, Gamain Benoit   +2 more
exaly   +4 more sources

Receptor Affinity-Based Purification of PfEMP1 Proteins

2022
The virulence of Plasmodium falciparum is linked to the ability of infected erythrocytes (IEs) to bind a range of human receptors. This binding is mediated by a family of highly polymorphic proteins known as P. falciparum erythrocyte membrane protein 1 (PfEMP1).
Rebecca W. Olsen, Jennifer Suurbaar, Anja Ramstedt Jensen   +2 more
openaire   +3 more sources

Production of PfEMP1-Specific Mouse Monoclonal Antibodies

2022
The PfEMP1 family of proteins expressed on the Plasmodium falciparum-infected erythrocyte (IE) surface is the main target of naturally acquired immunity against malaria. Antibodies capable of opsonizing the IEs and blocking the binding between PfEMP1 and human receptors seems to be one of the main protective mechanisms of the naturally acquired ...
Dalgaard, Nanna, Barfod, Lea
openaire   +3 more sources

Analysis of Antibody Inhibition of PfEMP1 Binding by Competition ELISA

2022
Plasmodium falciparum express variant antigens on the surface of infected erythrocytes (IEs). These include proteins of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. PfEMP1 proteins mediate binding of IEs to various human endothelial receptors and induce antibodies response during natural infections.
Rebecca W. Olsen, Jennifer Suurbaar, Anja Ramstedt Jensen   +2 more
openaire   +3 more sources

Production of anti-PfEMP1 Polyclonal Antisera in Rats and Mice

2022
Plasmodium falciparum-infected erythrocytes (IEs) bind various host receptors via members of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family expressed on the surface of the IEs. Antibody reagents are needed to investigate interactions between specific PfEMP1 proteins and receptors expressed by human endothelial cells.
Rebecca W. Olsen, Jennifer Suurbaar, Anja Ramstedt Jensen   +2 more
openaire   +3 more sources