Results 141 to 150 of about 2,727 (170)
Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria [PDF]
Cell Host and Microbe, 2017 Brain swelling is a major predictor of mortality in pediatric cerebral malaria (CM). However, the mechanisms leading to swelling remain poorly defined. Here, we combined neuroimaging, parasite transcript profiling, and laboratory blood profiles to develop machine-learning models of malarial retinopathy and brain swelling.
Selasi Dankwa +2 more
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Host receptor binding induces conformational changes in a PfEMP1 protein
Structure, 2023In this issue of Structure, Raghavan et al. present the cryo-EM structures of the malaria-associated group A PfEMP1 HB3VAR03 head in both host receptor-free and receptor-bound states. The structures are complemented by biophysical analysis and introduce an innovative model in which host-receptor binding induces conformational changes in a PfEMP1 ...
Rui, Ma, Niraj H, Tolia
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Surface Plasmon Resonance Analysis of PfEMP1 Interaction with Receptors
2022A detailed understanding of the interaction between the highly variant Plasmodium falciparum erythrocyte membrane proteins 1 (PfEMP1) and their human binding partners is essential to explain their roles in disease development in malaria, as well as to understand how antibodies can inhibit these interactions and how the parasite manages to evade such an
Frank, Lennartz, Matthew K, Higgins
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Role of Nonimmune IgG Bound to PfEMP1 in Placental Malaria
Science, 2001Infections with Plasmodium falciparum during pregnancy lead to the accumulation of parasitized red blood cells (infected erythrocytes, IEs) in the placenta. IEs of P. falciparum isolates that infect the human placenta were found to bind immunoglobulin G (IgG).
K, Flick +6 more
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Expression of Large Full-Length PfEMP1 Proteins in HEK293 Cells
2022Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a family of proteins expressed on the surface of red blood cells infected by Plasmodium falciparum. PfEMP1 proteins play a vital role in parasite virulence, and thus are important vaccine candidates to prevent severe disease.
Jonathan Paul Renn +2 more
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Affinity Purification of PfEMP1-Specific Antibodies from Human Blood
2022Acquired immunity against Plasmodium falciparum infections relies heavily on IgG antibodies specific for PfEMP1 proteins expressed on the surface of infected erythrocytes. Purified human antibodies can be used, for example, to study the interactions between specific PfEMP1 proteins and receptors expressed by human endothelial cells, and to identify ...
Rebecca W. Olsen +2 more
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A family affair: var genes, PfEMP1 binding, and malaria disease
Current Opinion in Microbiology, 2006An immunovariant adhesion protein family in Plasmodium falciparum named erythrocyte membrane protein 1 (PfEMP1), encoded by var genes, is responsible for both antigenic variation and cytoadhesion of infected erythrocytes at blood microvasculature sites throughout the body. Elucidation of the genome sequence of P.
Susan M, Kraemer, Joseph D, Smith
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Definition of the minimal domain of CIDR1α of Plasmodium falciparum PfEMP1 for binding CD36
Molecular and Biochemical Parasitology, 2002Louis H Miller +2 more
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Characterization of anti-var2CSA-PfEMP1 cytoadhesion inhibitory mouse monoclonal antibodies
Microbes and Infection, 2006Pregnancy-associated malaria (PAM) is associated with the massive sequestration of erythrocytes infected with CSA-binding parasites in the placenta. Natural protective immunity against PAM is acquired during the course of pregnancies, with the development of anti-PfEMP1 antibodies recognizing placental infected erythrocytes (IEs) from different ...
Marion, Avril +5 more
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Expressing Full-Length Functional PfEMP1 Proteins in the HEK293 Expression System
2012Due to the A/T-richness of the genome of Plasmodium falciparum, expressing P. falciparum proteins in heterologous expression systems is challenging. In addition, many P. falciparum proteins have high cysteine content and high molecular weight, which further complicates expression of these proteins in heterologous systems.
Srivastava, Anand +2 more
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