Results 151 to 160 of about 2,727 (170)

Glycophorin B-PfEMP1 interaction mediates robust rosetting in Plasmodium falciparum

International Journal of Biological Macromolecules
P. falciparumerythrocyte membrane protein 1 (PfEMP1) is the major parasite protein responsible for rosetting by binding to host receptors such as heparan sulfate, CR1 on RBC surface. Usually monomeric protein-carbohydrate interactions are weak [1], therefore PfEMP1 binds to plasma proteins like IgM or α2-macroglobulin that facilitate its clustering on ...
Bijayeeta, Deb, Adrita, Das, Ramya, Vilvadrinath, Arvind, Jangra, Madhavi Sanjay, Shukla, Reetesh Raj, Akhouri, Suchi, Goel   +6 more
openaire   +2 more sources

A model of the complex between the PfEMP1 malaria protein and the human ICAM‐1 receptor

Proteins: Structure, Function, and Bioinformatics, 2007
AbstractMalaria is caused by protozoan parasites of the genus Plasmodium. Four species of Plasmodium can infect humans: P. falciparum, P. malariae, P. vivax, and P. ovale. P. falciparum is the only able to cytoadhere to the surface of postcapillary endothelial cells.
Claudia Bertonati, TRAMONTANO, ANNA
openaire   +3 more sources

The Role of PfEMP1 Expression and Immunity in Ugandian Children with Severe Malaria

2022
Indiana University-Purdue University Indianapolis (IUPUI)
openaire   +2 more sources

Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria

EMBO Reports, 2022
Jacob Strahilevitz, Karina Simantov, Olga Yajuk   +2 more
exaly  

Rosette-mediating PfEMP1 variants: conservation and strain-transcending antibodies

2022
Plasmodium falciparum malaria is one of the leading causes of child mortality worldwide, and currently there is no vaccine which confers sterilising immunity against infection. One approach to reducing the morbidity and mortality associated with P. falciparum malaria would be the development of a vaccine which targets P. falciparum virulence phenotypes,
openaire   +2 more sources

PfEMP1-Specific Immunoglobulin G Reactivity Among Beninese Pregnant Women With Sickle Cell Trait

Open Forum Infectious Diseases, 2021
Mary Lopez-Perez, Firmine Viwami, Zakaria Seidu   +2 more
exaly  

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

Immunological Reviews, 2020
Anja T R Jensen, Yvonne Adams, Lars Hviid   +2 more
exaly  

Dynamics of PfEMP1 Antibody Profile From Birth to 12 Months of Age in Beninese Infants

Journal of Infectious Diseases, 2020
Justin Doritchamou, Adrian J F Luty, Nicaise Tuikue Ndam   +2 more
exaly  

Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence

Proceedings of the National Academy of Sciences of the United States of America, 2021
Yvonne Azasi, Leanne M Low, Ashley N Just   +2 more
exaly  

Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria

Cell Host and Microbe, 2017
Yvonne Adams, Anja Bengtsson, Rebecca W Olsen   +2 more
exaly