Results 91 to 100 of about 419,158 (294)

Deeper Capacity Building for Greater Impact: Designing a Long-Term Initiative to Strengthen a Set of Nonprofit Organizations [PDF]

, 2007
Offers advice about how to plan, implement, and evaluate long-term, capacity-building initiatives -- sustained efforts to help a select group of nonprofit grantees reach a new level of ...
Paul Connolly
core  

Real‐World Treatment and Outcomes in Resectable Early‐Stage Non‐Small Cell Cancer: THASSOS‐INTL Australia Cohort

AGING MEDICINE, EarlyView.
Australia cohort of THASSOS‐INTL; non‐interventional, multicenter, retrospective study provides insights into treatment patterns and associated survival outcomes in patients with resectable stage I‐III NSCLC in the pre‐immunotherapy era. Neoadjuvant and adjuvant therapy was reported in < 10% and < 40% patients, respectively.
Pei Ding, Kevin Jasas, Victoria Bray, Abhijit Pal, Rebecca Moor   +4 more
wiley   +1 more source

The development of a staphylococcus aureus four antigen vaccine for use prior to elective orthopedic surgery

Human Vaccines & Immunotherapeutics, 2019
Staphylococcus aureus (S. aureus) is a challenging bacterial pathogen which can cause a range of diseases, from mild skin infections, to more serious and invasive disease including deep or organ space surgical site infections, life-threatening bacteremia,
A. Gurtman, E. Begier, N. Mohamed, J. Baber, C. Sabharwal, R.M. Haupt, H. Edwards, D. Cooper, K.U. Jansen, A.S. Anderson   +9 more
doaj   +1 more source

Relationship Between Hospital Volume and Outcomes of Minimally Invasive Esophagectomy for Esophageal Cancer: Analysis of the National Clinical Database in Japan

Annals of Gastroenterological Surgery, EarlyView.
According to multivariable analysis conducted using a hierarchical logistic regression model, using VHH as the reference group, the odds ratios for mortality by hospital volume category were as follows: VLH, 2.70 (p < 0.0001); LH, 1.72 (p = 0.052); MH, 1.70 (p = 0.034); and HH, 1.43 (p = 0.173).
Soji Ozawa, Hiraku Kumamaru, Yuko Kitagawa, Kazuo Koyanagi, Junya Oguma, Harushi Udagawa, Hiroaki Miyata, Yasushi Toh, Hisahiro Matsubara   +8 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

Immunologic and biophysical features of the BNT162b2 JN.1 and KP.2 adapted COVID-19 vaccines

Nature Communications
The rise in prevalence of the SARS-CoV-2 JN.1 lineage in 2023 and subsequent derivative sublineages coincided with reduced neutralizing activity and effectiveness of XBB.1.5-adapted vaccines.
Wei Chen, Kristin R. Tompkins, Ian W. Windsor, Lyndsey T. Martinez, Minah Ramos, Weiqiang Li, Shikha Shrivastava, Swati Rajput, Jeanne S. Chang, Parag Sahasrabudhe, Kimberly F. Fennell, Thomas J. McLellan, Graham M. West, Kristianne P. Dizon, Aaron Yam, Siddartha Mitra, Subrata Saha, Daiana Sharaf, Andrew P. McKeen, Carla I. Cadima, Alexander Muik, Wesley Swanson, Raquel Munoz Moreno, Pilar Mendoza Daroca, Ugur Sahin, Annaliesa S. Anderson, Huixian Wu, Kena A. Swanson, Kayvon Modjarrad   +28 more
doaj   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

In-Clinic and Natural Gait Observations master protocol (I-CAN-GO) to validate gait using a lumbar accelerometer

Scientific Reports
Traditional measurements of gait are typically performed in clinical or laboratory settings where functional assessments are used to collect episodic data, which may not reflect naturalistic gait and activity patterns.
Miles Welbourn, Paul Sheriff, Pirinka Georgiev Tuttle, Lukas Adamowicz, Dimitrios Psaltos, Amey Kelekar, Jessica Selig, Andrew Messere, Winnie Mei, David Caouette, Sana Ghafoor, Mar Santamaria, Hao Zhang, Charmaine Demanuele, F. Isik Karahanoglu, Xuemei Cai   +15 more
doaj   +1 more source

Strengthening Career Guidance for New Jersey High School Students [PDF]

, 2003
This report is based on the findings of a conference held in October 2003 by the Heldrich Center and the State of New Jersey. The report includes the highlights of major speeches by Heldrich Center director Van Horn, Labor Commissioner Kroll, and ...
Denise Pierson-Balik, Stephanie Duckworth-Elliott   +1 more
core  

Navigating the Post‐BCMA/GPRC5D Landscape: Efficacy of Selinexor, Bortezomib, and Dexamethasone After Sequential Immunotherapy Failure in Penta‐Refractory Multiple Myeloma—A Multicenter Analysis

American Journal of Hematology, EarlyView.
ABSTRACT Patients with relapsed/refractory multiple myeloma (RRMM) who are penta‐drug refractory, defined as resistant to two proteasome inhibitors, two immunomodulatory agents, and an anti‐CD38 monoclonal antibody, face a dismal prognosis, particularly after exposure to T‐cell–redirecting therapies.
Maximilian Al‐Bazaz, Winfried Alsdorf, Lisa Leypoldt, Piet Sonnemann, Christoph Schaefers, Jule Artzenroth, Marie Harzer, Abdulaziz Kamili, Leandra Bartke, Leon Cords, Jan Vorwerk, Theo Leitner, Markus Maulhardt, Kerstin Brinkert, Annamaria Brioli, Tim Richardson, Udo Holtick, Stefan M. Hillmann, Hans Salwender, Cyrus Khandanpour, Carsten Bokemeyer, Katja Weisel, Ricardo Kosch   +22 more
wiley   +1 more source