Results 81 to 90 of about 419,158 (294)
Nature CommunicationsSeveral hydroxysteroid dehydrogenase 17-beta 13 variants have previously been identified as protective against metabolic dysfunction-associated steatohepatitis (MASH) fibrosis, ballooning and inflammation, and as such this target holds significant ...
Michelle R. Garnsey +41 more
doaj +1 more source
Pregabalin long-term treatment and assessment of discontinuation in patients with generalized anxiety disorder [PDF]
, 2013 This study was funded by Pfizer Inc. Editorial support to prepare this manuscript for submission was provided by Lorna Forse, PhD, of Engage Scientific Solutions and funded by Pfizer ...
DuBrava, Sarah +7 more
core +1 more source
Cognitive Trajectories from Preclinical Alzheimer's Disease to Dementia
Advanced Science, EarlyView.A continuous, multi‐domain characterization of cognitive decline across the Alzheimer's disease spectrum identifies when individual cognitive measures become abnormal. Episodic memory declines first, followed by executive function, language, processing speed, and visuospatial abilities, supporting improved clinical interpretation and optimized endpoint
Fredrik Öhman +3 more
wiley +1 more source
Scientific ReportsDigital health technologies (DHTs) are increasingly being adopted in clinical trials, as they enable objective evaluations of health parameters in free-living environments.
N. Camerlingo +12 more
doaj +1 more source
Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity
Advanced Science, EarlyView.Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu +8 more
wiley +1 more source
npj Digital MedicineThe Acute Respiratory Illness Surveillance (AcRIS) Study was a low-interventional trial that examined voice changes with respiratory illnesses. This longitudinal trial was the first of its kind, conducted in a fully decentralized manner via a Bring Your ...
Mar Santamaria +20 more
doaj +1 more source
Advanced Science, EarlyView.Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo +7 more
wiley +1 more source
Scientific ReportsWe previously reported that all doses of ibuzatrelvir, an oral SARS-CoV-2 Mpro inhibitor, twice daily for 5 days significantly reduced viral RNA levels (viral load [VL]) from baseline compared with placebo among adults without risk factors for severe ...
Jin Hyang Kim +11 more
doaj +1 more source
GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis
Advanced Science, EarlyView.This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang +9 more
wiley +1 more source
npj VaccinesHerpes zoster (HZ) is a painful vesicular rash that occurs upon varicella-zoster virus (VZV) reactivation in older adults and immunocompromised individuals.
Raquel Munoz-Moreno +18 more
doaj +1 more source