Results 61 to 70 of about 274,980 (287)

A Novel Decellularized Fibrocartilage Graft Promotes Tympanic Membrane Repair

Advanced Healthcare Materials, EarlyView.
An off‐the‐shelf decellularized porcine meniscus fibrocartilage graft (MEND) is engineered for pediatric tympanoplasty. Featuring a microchannel architecture that promotes host cell invasion, MEND rapidly closes tympanic membrane perforations and fully remodels in vivo, outperforming fascia and matching cartilage grafts while avoiding donor‐site ...
Paul M. Gehret, Ryan M. Friedman, Gautham Nair, Stephanie L. Fung, Dana D. Ragbirsingh, John Germiller, Riccardo Gottardi   +6 more
wiley   +1 more source

Equity Research - Pfizer Inc.

, 2015
Mestrado em FinançasA Pfizer Inc é uma empresa líder no desenvolvimento e comercialização de produtos biofarmacêuticos com um portfólio global que inclui medicamentos e vacinas, bem como diversos produtos de cuidados de saúde mundialmente conhecidos. Nos
Baião, Marcos Miguel Lourenço dos Santos
core   +2 more sources

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Equity research - Pfizer Inc.

, 2021
Mestrado Bolonha em FinançasThis report includes a detailed valuation of Pfizer Inc. The format of this Equity Research Report combines both rules of ISEG Master Final Work Project and the CFA institute recommendations.
Ventura, João Diogo Livreiro
core   +1 more source

Necktie

, 2004
Tie of silk geometric weave in dark blue and gold formulated around the little blue Pfizer pill, Viagra.
Pfizer
core  

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants

Nature Communications
Several hydroxysteroid dehydrogenase 17-beta 13 variants have previously been identified as protective against metabolic dysfunction-associated steatohepatitis (MASH) fibrosis, ballooning and inflammation, and as such this target holds significant ...
Michelle R. Garnsey, Yang Wang, David J. Edmonds, Matthew F. Sammons, Benjamin Reidich, Youngwook Ahn, Yotam Ashkenazi, Anthony Carlo, Matthew A. Cerny, Karen J. Coffman, Jeffrey A. Culver, Anne-Marie Dechert Schmitt, Heather Eng, Ethan L. Fisher, Jemy A. Gutierrez, Larry James, Samantha Jordan, Jeffrey T. Kohrt, Melissa Kramer, Erik A. LaChapelle, Jack C. Lee, Jisun Lee, Dongmei Li, Zhenhong Li, Shenping Liu, Jianhua Liu, Thomas V. Magee, Melissa R. Miller, Michael Moran, Deane M. Nason, Nicole L. Nedoma, Steven V. O’Neil, Mary A. Piotrowski, Jillian Racich, Ruth F. Sommese, Lucy M. Stevens, Ann S. Wright, Jun Xiao, Liying Zhang, Dahui Zhou, Ornella Barrandon, Michelle F. Clasquin   +41 more
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Measuring gait parameters from a single chest-worn accelerometer in healthy individuals: a validation study

Scientific Reports
Digital health technologies (DHTs) are increasingly being adopted in clinical trials, as they enable objective evaluations of health parameters in free-living environments.
N. Camerlingo, X. Cai, L. Adamowicz, M. Welbourn, D. J. Psaltos, H. Zhang, A. Messere, J. Selig, W. Lin, P. Sheriff, C. Demanuele, M. Santamaria, F. I. Karahanoglu   +12 more
doaj   +1 more source