Results 71 to 80 of about 274,980 (287)

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

Longitudinal voice monitoring in a decentralized Bring Your Own Device trial for respiratory illness detection

npj Digital Medicine
The Acute Respiratory Illness Surveillance (AcRIS) Study was a low-interventional trial that examined voice changes with respiratory illnesses. This longitudinal trial was the first of its kind, conducted in a fully decentralized manner via a Bring Your ...
Mar Santamaria, Yiorgos Christakis, Charmaine Demanuele, Yao Zhang, Pirinka Georgiev Tuttle, Fahimeh Mamashli, Jiawei Bai, Rogier Landman, Kara Chappie, Stefan Kell, John G. Samuelsson, Kisha Talbert, Leonardo Seoane, W. Mark Roberts, Edmond Kato Kabagambe, Joseph Capelouto, Paul Wacnik, Jessica Selig, Lukas Adamowicz, Sheraz Khan, Robert J. Mather   +20 more
doaj   +1 more source

Pfizer -- 1964-66 -- OPV Production, National -- letter, 1964-09-23

, 1964
Letter from Rosenthal, Milton to Charles Pfizer & Co., Inc.
Rosenthal, Milton
core  

Case note on "Pfizer"

, 2014
Case note on ...
Marco Bellia
core   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Ibuzatrelvir potently reduced viral RNA levels despite a high rate of anti-S seropositivity: a post hoc analysis of serology of the phase 2b study

Scientific Reports
We previously reported that all doses of ibuzatrelvir, an oral SARS-CoV-2 Mpro inhibitor, twice daily for 5 days significantly reduced viral RNA levels (viral load [VL]) from baseline compared with placebo among adults without risk factors for severe ...
Jin Hyang Kim, Alex Knutson, Justin Smith, Shunjie Guan, Luke F. Chen, Mahta Mortezavi, Abigail Sloan, Anindita Banerjee, Mary Lynn Baniecki, Craig Hyde, Charlotte Allerton, Negar Niki Alami   +11 more
doaj   +1 more source

Relationship Between Hospital Volume and Outcomes of Minimally Invasive Esophagectomy for Esophageal Cancer: Analysis of the National Clinical Database in Japan

Annals of Gastroenterological Surgery, EarlyView.
According to multivariable analysis conducted using a hierarchical logistic regression model, using VHH as the reference group, the odds ratios for mortality by hospital volume category were as follows: VLH, 2.70 (p < 0.0001); LH, 1.72 (p = 0.052); MH, 1.70 (p = 0.034); and HH, 1.43 (p = 0.173).
Soji Ozawa, Hiraku Kumamaru, Yuko Kitagawa, Kazuo Koyanagi, Junya Oguma, Harushi Udagawa, Hiroaki Miyata, Yasushi Toh, Hisahiro Matsubara   +8 more
wiley   +1 more source

Adult RSV Vaccination: What Is the Role of RSV Subgroup in Disease Prevention?

Infectious Diseases and Therapy
Respiratory syncytial virus (RSV) cocirculates as two antigenic subgroups, RSV A and RSV B, with irregular dominance by season. Despite highly conserved fusion (F) protein epitopes, sequence, and antigenic differences between A and B, especially within ...
S. Elizabeth Williams, Giovanni Checcucci Lisi, Kate Luisi, Kumar Ilangovan, Cassandra Hall-Murray, Kyla Hayford, Elizabeth Begier   +6 more
doaj   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

A highly stable lyophilized mRNA vaccine for Herpes Zoster provides potent cellular and humoral responses

npj Vaccines
Herpes zoster (HZ) is a painful vesicular rash that occurs upon varicella-zoster virus (VZV) reactivation in older adults and immunocompromised individuals.
Raquel Munoz-Moreno, Viola Allaj, Eddie Gadee, Julie M. Button, Fernando Diaz, Mohan S. Maddur, Wei Chen, Cheng Hui Hu, Lyndsey Martinez, Andreas Giannakou, Adam Lee Campbell, Yana Miteva, Pengbo Guo, Bridget Huang, Shuai Shi, Jason Lotvin, Kristin Tompkins, Pirada Suphaphiphat Allen, Alicia Solórzano   +18 more
doaj   +1 more source