Results 61 to 70 of about 19,054 (239)

Stochastic Pharmacokinetic-Pharmacodynamic Modeling for Assessing the Systemic Health Risk of Perfluorooctanoate (PFOA) [PDF]

, 2018
A phase 1 dose-escalation trial assessed the chemotherapeutic potential of ammonium perfluorooctanoate (APFO). Forty-nine primarily solid-tumor cancer patients who failed standard therapy received weekly APFO doses (50mg-1200mg) for six-weeks.
Albrecht, Barnett, Barry, Bartell, Benbrahim-Tallaa, Biegel, Bjork, Blanco-Aparicio, Buck, Butenhoff, Butenhoff, Butenhoff, Butenhoff, Butenhoff, Butenhoff, C8 Science Panel, C8 Science Panel, Caverly Rae, Chang, Chang, Consonni, Cook, Corton, Costa, Darrow, Das, Dhingra, Dhingra, Dousdampanis, Elcombe, Elcombe, Eriksen, Fitz-Simon, Frisbee, Gallo, Geiger, Geiger, Gonzalez, Han, Haughom, Kataria, Kennedy, Klaunig, Knox, Koulouri, Le Tourneau, Lin, Lindhardt, Lopez-Espinosa, Lou, Loveless, Luebker, Lüdtke, MacPherson, Melzer, Minata, Nelson, Olsen, Olsen, Olsen, Princen, Raleigh, Rebholz, Rosen, Roy, Russell, Sakr, Sakr, Saltelli, Shankar, Shankar, Shepherd, Sobol, Son, Starling, Steenland, Steenland, Steenland, Steenland, Steenland, Therasse, US EPA, US EPA, Verner, Wang, Watkins, Webster, Weiss, Wen, Westerterp, Winquist, Winquist, Woodward, Zhao   +93 more
core   +7 more sources

Network Pharmacology and In Vivo Evaluation of Lycium barbarum Polysaccharide in Preventing Perfluorooctanoic Acid-Induced Damage in Broilers

Poultry Science
To examine the guarding effects of Lycium barbarum polysaccharides (LBP) on liver and gut injury induced by perfluorooctanoic acid (PFOA) in broilers. Initially, a dose selection experiment for PFOA modeling was conducted.
Nana Gao, Wenmei Yao, Yang Li, Xu Liu, Heping Bai, Xiaodan Wang   +5 more
doaj   +1 more source

PFAS properties and destruction methods: A focus on enzymatic degradation

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Per‐ and polyfluoroalkyl substances (PFAS) are known as ‘forever’ chemicals and have lasting detrimental impact on the environment and living organisms. To understand PFAS molecules better, this review begins with an overview of PFAS definition, classifications and applications, and then provides a comprehensive summary and critical analysis ...
Guobin Liang, Hua Zhao
wiley   +1 more source

Congener specific organic carbon normalized soil and sediment-water partitioning coefficients for the C1 through C8 perfluorinated alkylsulfonic and alkylcarboxylic acids [PDF]

, 2009
Organic carbon normalized soil and sediment-water partitioning (Koc) coefficients were estimated for all C1 through C8 perfluorinated alkylsulfonic acid (PFSA) and alkylcarboxylic acids (PFCA) congeners.
Kaya Forest, Sierra Rayne
core   +1 more source

Determinants of Hair Manganese, Lead, Cadmium and Arsenic Levels in Environmentally Exposed Children. [PDF]

, 2018
Biomarkers of environmental metal exposure in children are important for elucidating exposure and health risk. While exposure biomarkers for As, Cd, and Pb are relatively well defined, there are not yet well-validated biomarkers of Mn exposure.
Jursa, Thomas, Smith, Donald R, Stein, Cheryl R   +2 more
core   +2 more sources

Characteristics, properties and limitations of per‐ or polyfluoroalkyl substances (PFASs) and fluoropolymers

Polymer International, EarlyView.
An overview and categorization of man‐made per‐ or polyfluoroalkyl substances (PFASs) including low‐molar‐mass and high‐molar‐mass fluorochemicals, and their international regulations is presented. Though certain PFASs are toxic, bioaccumulative and cross the human cellular membranes, others, such as fluoropolymers, are safe, reliable and involved in ...
Bruno Améduri
wiley   +1 more source

Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1 month. [PDF]

, 2019
BACKGROUND:Early disruption of the microbial community may influence life-long health. Environmental toxicants can contaminate breast milk and the developing infant gut microbiome is directly exposed.
Dahl, Cecilie, Eggesbø, Merete, González, Antonio, Iszatt, Nina, Janssen, Stefan, Knight, Rob, Lenters, Virissa, Mandal, Siddhartha, Midtvedt, Tore, Peddada, Shyamal, Stigum, Hein   +10 more
core  

A network biology-based approach to evaluating the effect of environmental contaminants on human interactome and diseases

, 2018
Environmental contaminant exposure can pose significant risks to human health. Therefore, evaluating the impact of this exposure is of great importance; however, it is often difficult because both the molecular mechanism of disease and the mode of action
Iida, Midori, Takemoto, Kazuhiro
core   +1 more source

Prenatal Exposure to Perfluoroalkyl Acids and Serum Testosterone Concentrations at 15 Years of Age in Female ALSPAC Study Participants [PDF]

, 2015
Background: Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator–activated receptor alpha (PPARα) subtype activity, which influences lipid metabolism.
Ankarberg A, Antonia M. Calafat, Hany Lashen, Jouni J.K. Jaakkola, Michele Marcus, Mildred Maisonet   +5 more
core   +2 more sources

Water-to-air transfer of branched and linear PFOA: Influence of pH, concentration and water type

Emerging Contaminants, 2017
The volatilisation of perfluorooctanoic acid (PFOA) was measured experimentally at a range of pH values using a previously published laboratory method. Water-to-air transfer was studied for five structural isomers, namely: the linear isomer (n-PFOA) and ...
Jana H. Johansson, Hong Yan, Urs Berger, Ian T. Cousins   +3 more
doaj   +1 more source