Results 101 to 110 of about 49,868 (226)

Erratum to "Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia" [Biomol. Ther. 28 (2020) 240-249]

Biomolecules & Therapeutics, 2021
Lee, Jun Hee, Han, Yong-Seok, Lee, Sang Hun   +2 more
openaire   +3 more sources

Early changes in muscle atrophy and muscle fiber type conversion after spinal cord transection and peripheral nerve transection in rats [PDF]

, 2013
BACKGROUND: Spinal cord transection and peripheral nerve transection cause muscle atrophy and muscle fiber type conversion. It is still unknown how spinal cord transection and peripheral nerve transection each affect the differentiation of muscle fiber ...
Katsuyoshi Suganuma, Kiminori Yukata, Kosaku Higashino, Natsuo Yasui, Tetsuya Matsuura, Toshihiko Nishisho   +5 more
core   +1 more source

Macrophage PPAR gamma Co‐activator‐1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid

EMBO Molecular Medicine, 2013
Conjugated linoleic acid (CLA) has the unique property of inducing regression of pre‐established murine atherosclerosis. Understanding the mechanism(s) involved may help identify endogenous pathways that reverse human atherosclerosis.
Cathal McCarthy, Nora T. Lieggi, Denis Barry, Declan Mooney, Monica de Gaetano, William G. James, Sarah McClelland, Mary C. Barry, Laure Escoubet‐Lozach, Andrew C. Li, Christopher K Glass, Desmond J. Fitzgerald, Orina Belton   +12 more
doaj   +1 more source

The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases

Exploration, EarlyView.
This review explores the critical role of mitochondria in heart development and cardiovascular disease. It highlights how mitochondrial maturation during embryonic‐to‐postnatal transition, regulated by oxygen and metabolic changes, shapes cardiac structure and function.
Minghao Li, Ruiyi Zhang, Xinyuan Li, Hefeng Huang   +3 more
wiley   +1 more source

PGC‐1α overexpression increases transcription factor EB nuclear localization and lysosome abundance in dystrophin‐deficient skeletal muscle

Physiological Reports, 2020
Duchenne muscular dystrophy (DMD) is caused by the absence of functional dystrophin protein and results in progressive muscle wasting. Dystrophin deficiency leads to a host of dysfunctional cellular processes including impaired autophagy.
Hannah R. Spaulding, Amanda K. Ludwig, Katrin Hollinger, Matthew B. Hudson, Joshua T. Selsby   +4 more
doaj   +1 more source

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source

Progress on the Protective Effect and the Mechanism of Chinese Medicine Injection and Chinese Medicine Monomeric Small Molecules on Sepsis‐Related Liver Injury

Gut Medicine, EarlyView.
ABSTRACT Sepsis‐related liver injury (SRLI) involves multiple interrelated pathological processes, including excessive inflammation, oxidative imbalance, mitochondrial dysfunction, dysregulated autophagy, and microcirculatory impairment. Increasing evidence indicates that traditional Chinese medicine (TCM)–based interventions, particularly Chinese ...
Xiang Yunsheng, Yan Yumeng
wiley   +1 more source

Interval training normalizes cCardiomyocyte function, diastolic Ca²⁺ control, and SR Ca²⁺ release synchronicity in a mouse model of diabetic cardiomyopathy [PDF]

, 2009
In the present study we explored the mechanisms behind excitation-contraction (EC)-coupling defects in cardiomyocytes from mice with type-2 diabetes (db/db), and determined whether 13-weeks of aerobic interval training could restore cardiomyocyte Ca2 ...
Aasum, E., Catalucci, D., Ceci, M., Condorelli, G., Høydal, M.A., Kemi, O.J., Larsen, T., Rolim, N., Smith, G.L., Stølen, T.O., Wisløff, U.   +10 more
core   +2 more sources

Thyroid Hormone Induces PGC-1α during Dendritic Outgrowth in Mouse Cerebellar Purkinje Cells

Frontiers in Cellular Neuroscience, 2017
Thyroid hormone 3,3′,5-Triiodo-L-thyronine (T3) is essential for proper brain development. Perinatal loss of T3 causes severe growth defects in neurons and glia, including strong inhibition of dendrite formation in Purkinje cells in the cerebellar cortex.
Tetsu Hatsukano, Tetsu Hatsukano, Junko Kurisu, Kansai Fukumitsu, Kansai Fukumitsu, Kazuto Fujishima, Mineko Kengaku, Mineko Kengaku   +7 more
doaj   +1 more source

Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition [PDF]

, 2019
Background: Platinum-based chemotherapy remains the standard of care for most lung cancer cases. However chemoresistance is often developed during the treatment, limiting clinical utility of this drug.
Alfaro, Cristina, Calvo, Virginia, Coronado, Maria José, Cruz-Bermúdez, Alberto, Franco, Fernando, Garcia, José Miguel, García-Grande, Aránzazu, Laine-Menéndez, Sara, Laza-Briviesca, Raquel, Lendinez, Cristina, Martín Acosta, Paloma, Martín Ruiz-Valdepeñas, Asunción, Moreno-Villa, M. Rocío, Palacios-Zambrano, Sara, Provencio, Mariano, Romero, Atocha, Salas, Clara, Vicente-Blanco, Ramiro J.   +17 more
core   +2 more sources