Results 141 to 150 of about 122,171 (336)
What's New? Novel immunomodulatory insights derived from experimental models and clinical samples reveal the cancer‐preventive potential of intermittent low‐dose erlotinib plus sulindac (ERL + SUL). This study shows that ERL + SUL treatment upregulates MHC class I and II expression and remodels the immune cell niche, with significant tumor suppression ...
Chakrapani Tripathi+17 more
wiley +1 more source
Dendritic-Cell (DC)-Based Immunotherapy: Tumor Endothelial Marker 8 (TEM8) Gene Expression of DC Vaccines Correlates with Clinical Outcome [PDF]
\ud Previous studies have shown that tumor-endothelial markers (TEMs) are upregulated in immunosuppressive, pro-angiogenic dendritic cells (DCs) found in tumor microenvironments. \ud We reported that pro-angiogenic monocyte-derived DCs (Mo-DCs), utilized
Bolli, Elisabetta+2 more
core
Membrane-associated interleukin 1 activity on human U937 tumor cells: stimulation of PGE2 production by human chondrosarcoma cells. [PDF]
V J Merluzzi+6 more
openalex +1 more source
Abstract Background Vaccinium corymbosum berries represent a source of anthocyanins and polyphenols studied and tested for their healthy potential. The present study was aimed at isolating, characterizing, and quantifying the anthocyanin‐enriched fraction obtained from blueberry and at assessing its biological and protective effects against head and ...
Giuseppe Falcone+11 more
wiley +1 more source
16,16-Dimethyl-PGE2 Protection Against α — Napthy lisothiocy anate - Induced Experimental Cholangitis in the Rat [PDF]
Mary J. Ruwart+4 more
openalex +1 more source
PGE2-Associated Inflammation and Gastrointestinal Tumorigenesis
Accumulating evidence has indicated that chronic inflammation is associated with a variety of diseases, including cancer, heart attacks, Alzheimer’s and other diseases. In the cancer research field, the association of inflammatory infiltration with cancer has been known histologically for a long time.
Hiroko Oshima, Masanobu Oshima
openaire +2 more sources
COX-1/PGE2/EP4 alleviates mucosal injury by upregulating β-arr1-mediated Akt signaling in colitis
COX-1/PGE2 is an important protective mediator in ulcerative colitis (UC). β-arrestin1 (β-arr1), which acts as a scaffold protein, is involved in PGE2-mediated signaling pathways.
Xiaojie Peng+7 more
doaj +1 more source
Immunomodulatory Effects of Omega‐3 Fatty Acids: Mechanistic Insights and Health Implications
Omega‐3 fatty acids, derived from dietary sources and supplements, serve as bioactive precursors (ALA, EPA, DHA) that integrate into immune cell membranes. These fatty acids enhance cell membrane fluidity, improve immune cell communication, and modulate key transcription factors like NF‐κB.
Mahmut Bodur+3 more
wiley +1 more source
Abstract Background Up to 33% of the general population worldwide suffer musculoskeletal conditions, with low back pain being the single leading cause of disability globally. Multimodal therapeutic options are available to relieve the pain associated with muscular disorders, including physical, complementary, and pharmacological therapies.
Jan Kyselovic+5 more
wiley +1 more source
The Cyclic-Amp-Lowering Effect Of Pge2 And Of The PGH2 Analog, U46619 [PDF]
B M Martin, C. Bonne
openalex +1 more source