PGE2 and IL‐6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox‐2 dependent pathway [PDF]
Susan V. Bukata+9 more
openalex +1 more source
The role of reactive enteric glia‐macrophage interactions in acute and chronic inflammation
Abstract Enteric glia are a heterogeneous population of peripheral glia within the enteric nervous system and play pivotal roles in gut homeostasis, tissue integrity, coordination of motility, and intestinal immune responses. Under physiological conditions, they communicate with enteric neurons to control intestinal motility.
Schneider Reiner+4 more
wiley +1 more source
Structural basis of human ABCC4 recognition of cAMP and ligand recognition flexibility. [PDF]
Wen X+6 more
europepmc +1 more source
In vitro studies with GI surgical specimens or biopsy are a critical step in translating preclinical studies in animals to humans before testing potential therapeutic interventions in expensive clinical trials. Routine availability of human gut specimens, in combination with technological advances and powerful new in vitro models of the human ENS from ...
Dmitrii Pavlov, Fievos L. Christofi
wiley +1 more source
Platelet secretions exert anti-inflammatory effects <i>in vitro</i> on neutrophils and uterine epithelia in cattle: a possible role in amplifying the uterine immune network toward pregnancy. [PDF]
Yousef MS+7 more
europepmc +1 more source
The pathophysiology of functional dyspepsia and irritable bowel syndrome includes altered motility, secretion, sensitivity to sensory signals, impaired epithelial barrier function, inflammation, and gut dysbiosis. The phytomedicine, STW 5‐II, represents a multi‐targeted approach, addressing these pathophysiologies.
Anita Annaházi+6 more
wiley +1 more source
Acetylsalicylic acid aggravates anaphylaxis in a PGE2-dependent manner. [PDF]
Globig P+5 more
europepmc +1 more source
Prostaglandins and Skin Cancer: An Old Pathway With New Insights in Cutaneous Oncology
International Journal of Dermatology, EarlyView.
Krisztian Nemeth
wiley +1 more source
Intestinal Dysmotility and Associated Disorders in Intestinal Muscle of Methylglyoxal‐Treated Mice
In patients undergoing long‐term peritoneal dialysis, intestinal transit capacity is often impaired, though the underlying mechanism remains unclear. Using a mouse model, we identified inflammation and impairment of interstitial cells of Cajal (ICC) in intestinal smooth muscle as potential contributors to this reduced transit capacity.
Yuki Yamakawa+2 more
wiley +1 more source