Results 211 to 220 of about 89,482 (299)

Advances and challenges in immunotherapy for intrahepatic cholangiocarcinoma based on the tumour immune microenvironment

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
This review integrates ICC‐specific and broader BTC evidence to define how desmoplastic stroma, immune‐cell crosstalk, metabolic remodelling, and molecular heterogeneity shape immunotherapy response and resistance. It highlights biomarker‐guided, mechanism‐based combinations while emphasizing the limited maturity of ICC‐specific evidence for emerging ...
Mengyao Chen, Shuofan Jin, Yuxuan Zhou, Jinkai Tong, Yufan Zhao, Quanjun Yang   +5 more
wiley   +1 more source

Comparison of simple and rapid collection methods for measuring salivary IL-6 and PGE₂ in cats with chronic gingivostomatitis: a pilot study. [PDF]

Braz J Vet Med
Gutierrez RCA, Bandini L, Requicha JF, Lourenço S, Gomes COMS.   +4 more
europepmc   +1 more source

A Super‐Resolution Approach for Astrocyte‐Specific Molecular Imaging Reveals the Nanoscale Distribution of Monoacylglycerol Lipase, the Metabolic Node Between Endocannabinoid and Prostaglandin Signaling

Glia, Volume 74, Issue 9, September 2026.
Dual‐color STORM resolves the precise architecture and protein distributions within hippocampal astrocytes at the nanoscale. Identification of a sparse but specific MAGL pool in CA1 astrocytic processes. Astrocytic MAGL is not synapse‐associated, suggesting a synapse‐independent role.
Miklós Zöldi, István Katona
wiley   +1 more source

Concurrent utilization of pregabalin and Zhengqing fengtongning sustained-release tablets in managing postherpetic neuralgia and its effect on pain relief, VAS scores, Insomnia Severity Index (ISI), SF-36, serum interleukin-17 (IL-17), prostaglandin E2 (PGE2). [PDF]

Postepy Dermatol Alergol
Luo H, Zhang W, Qiao M, Xin L.
europepmc   +1 more source

Pelvic venous disorders in women: Diagnosis and management for gynecologists

International Journal of Gynecology &Obstetrics, Volume 174, Issue 3, Page 1267-1276, September 2026.
Abstract Pelvic venous disorders (PeVD) are an underrecognized yet significant cause of chronic pelvic pain (CPP) in reproductive‐aged women, characterized by venous reflux, obstruction, or both. This clinical opinion provides a practical overview of PeVD for gynecologists, outlining its pathophysiology, common presentations, diagnostic approach, and ...
Tiffany Ni, Inbar Friedman, Jessica Smith, Brian Liu, Mary Melchior, Andrew D. Brown   +5 more
wiley   +1 more source

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels. [PDF]

Aging Cell
Zhao D, Fu J, Liu H, Liang S, Song M, Zhang A, Wang DE, Guo Q, Zhang Y, Wu J, Xu H.   +10 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Elevated calcitonin gene-related peptide expression through prostaglandin E2-EP4 receptor pathway in promoting proliferative periosteum formation in primary hypertrophic osteoarthropathy. [PDF]

J Orthop Translat
Pang Q, Zhou R, Li Y, Huang L, Xu J, Chi Y, Qi X, Li M, Jiang Y, Wang O, Xing X, Qin L, Xia W.   +12 more
europepmc   +1 more source

Selective Packaging of miR‐22 and miR‐29 Orthologues into Extracellular Vesicles of the Porcine Whipworm Trichuris Suis

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Helminths modulate host immunity, and in this respect, the porcine whipworm Trichuris suis has been explored clinically as an immunotherapy for inflammatory diseases. T. suis secretes a complex mixture of excretory/secretory products (ESP), including extracellular vesicles (EVs), nanosized membranous particles with bioactive cargoes of lipids,
Bradley Whitehead, Maibritt Mardahl, Eline P. Hansen, Bastian Fromm, Anne Borup, Anders Toftegaard Boysen, Jasmine C. L. Atay, Rikke Nørregaard, Allan Stensballe, Sidsel D. Andersen, Robin B. Gasser, Marco Brucale, Francesco Valle, Andrea Ridolfi, Eske Nøhr Glud, Merete Fredholm, Andrew R. Williams, Stig M. Thamsborg, Johan Palmfedt, Peter Nejsum   +19 more
wiley   +1 more source

Multimodal biomarker approach using urinary prostaglandin E2, kidney injury molecule-1 and resistive index for assessing kidney adaptation in transplant recipients. [PDF]

BMC Nephrol
Marbun MBH, Rodjani A, Rasyid N, Birowo P, Aditianingsih D, Matondang SBRE, Putra AR, Adhyatmoko B, Asaf MM, Septiar D, Khumaedi AI, Susalit E, Elita D, Safithri A, Widanarni K, Andina T, Mellenia J, Nainggolan PG, Heriyanto MC, Hutagulung ARTS.   +19 more
europepmc   +1 more source