Results 241 to 250 of about 89,482 (299)
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Suppression of human lymphocyte migration by PGE2
Inflammation, 1981Prostaglandin (PG) E2 markedly inhibits casein- and C5a-stimulated lymphocyte migration in a concentration-dependent manner. Inhibition is observed with as low as 10(-9) M PGE2 and requires that PGE2 be present during cell locomotion. Studies with PGE1, PGF1 alpha, PGF2 alpha and PGA1 indicate that only PGE1 and PGE2 inhibit lymphocyte migration. These
Dennis E van Epps +2 more
exaly +3 more sources
Inhibition of PGE2 in Subchondral Bone Attenuates Osteoarthritis
Cells, 2022 Aberrant subchondral bone architecture is a crucial driver of the pathological progression of osteoarthritis, coupled with increased sensory innervation.
Wenqing Xie, Yusheng Li, Ming Cai
exaly +2 more sources
Oral Oncology, 2010 The overexpression of cyclooxygenase (COX)-2 is a frequent event in squamous cell carcinomas of the head and neck (HNSCC), and non-steroidal anti-inflammatory drugs, which are potent inhibitors of COX-1 and COX-2, exert chemopreventive effects on HNSCC ...
Rogerio M Castilho +2 more
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Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney
Prostaglandins & Other Lipid Mediators, 2018Prostaglandin E2 (PGE2) is the most abundant prostanoid synthesized in the kidney and plays an important role in renal function. Physiologically, PGE2 regulates renal hemodynamics, water and sodium metabolism, blood pressure, and so on. As a well-known proinflammatory lipid mediator, PGE2 also substantially mediates renal injury under many ...
Jing, Wang +4 more
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PGE2 vs PGF2α in human parturition
Placenta, 2021Prostaglandin E2 (PGE2) and F2α (PGF2α) are the two most prominent prostanoids in parturition. They are involved in cervical ripening, membrane rupture, myometrial contraction and inflammation in gestational tissues. Because multiple receptor subtypes for PGE2 and PGF2α exist, coupled with diverse signaling pathways, the effects of PGE2 and PGF2α ...
Wen-Jiao, Li +6 more
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Intravaginal PGE2 in early abortion
Prostaglandins, 1974Abstract Intravaginal PGE2 was administered to 10 women in early (less than 50 days) pregnancy. Complete abortion was effected in 8, an incomplete abortion in one and one was a failure. Significant systemic side effects were noted in all subjects. Urinary hCG excretion rates prior to and on the 2nd and 14th day after PGE2 showed a decrease in all ...
James R. Jones +2 more
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Antifertility effects of PGE2 and PGF2α
Contraception, 1974Abstract The effectiveness of prostaglandins to modify egg transport, to stimulate uterine contractility and to induce luteolysis suggested their possible role as postcoital contraceptives. PGE 2 and PGF 2α were injected at 24 hours postcoitum (h p.c.) or at 4 days postcoitum (d p.c.) in rabbits. Effects on fertility were studied at autopsy 14 d p.c.
I, Aref, G H, Gottschewski, E S, Hafez
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Receptor binding in various tissues of PGE2, PGF2α and sulprostone, a novel PGE2-derivative
Prostaglandins, 1979Sulprostone is a tissue-specific PGE2-derivative with high abortifacient activity in various species including man. The dissociation constant KD of the receptor binding of this compound was compared with PGE2 and PGF2 alpha in various tissue preparations of different species.
E, Schillinger +3 more
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