Results 251 to 260 of about 158,535 (386)

On the mechanisms of brain blood flow regulation during hypoxia

The Journal of Physiology, Volume 603, Issue 8, Page 2263-2280, 15 April 2025.
Abstract figure legend Schematic illustration of key hypothesized mechanisms mediating the cerebrovascular response to hypoxia, suggested by the results of studies included in this analysis. Abstract The brain requires an uninterrupted supply of oxygen and nutrients to support the high metabolic needs of billions of nerve cells processing information ...
Alexander Mascarenhas, Alice Braga, Sara Maria Majernikova, Shereen Nizari, Debora Marletta, Shefeeq M. Theparambil, Qadeer Aziz, Nephtali Marina, Alexander V. Gourine   +8 more
wiley   +1 more source

Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity. [PDF]

EMBO Mol Med
Chang YC, Hsieh ML, Lee HL, Hee SW, Chang CF, Yen HY, Chen YA, Chen YR, Chou YW, Li FA, Ke YY, Chen SY, Hung MS, Hung AF, Huang JY, Chiu CH, Lin SY, Shih SF, Hsu CN, Hwang JJ, Yeh TK, Cheng TR, Liao KC, Laio D, Lin SW, Chen TY, Hu CM, Vogel U, Saar D, Kragelund BB, Tsou LK, Tseng YH, Chuang LM.   +32 more
europepmc   +1 more source

Bile salts-induced PGE2 release, PKCE and COX-2 expression, parallel the increased cellproliferation in an ex vivo model of Barrett's esophagus

, 2000
Baljeet Kaur, M. Bishr Omary, George Triadafilopoulos   +2 more
openalex   +1 more source

Exploring neuronal mechanisms of osteosarcopenia in older adults

The Journal of Physiology, EarlyView.
Abstract figure legend The mechanosensitive osteocytic network within the bone matrix acts as a receptor and plays a crucial role in the functional adaptation of bone to mechanical loading. Through mechanotransduction, osteocytes convert mechanical impulses into electrical signals, which are transmitted via afferent nerves to sympathetic preganglionic ...
Ilhan Karacan, Kemal Sıtkı Türker
wiley   +1 more source

Imrecoxib attenuates osteoarthritis by modulating synovial macrophage polarization through inactivating COX-2/PGE2 signaling pathway. [PDF]

Front Bioeng Biotechnol
Peng P, Zheng W, Liu Y, Huang J, Zhang B, Shen J, Cao J.   +6 more
europepmc   +1 more source

PGE2‐treated macrophages inhibit development of allergic lung inflammation in mice

Journal of Leukocyte Biology, 2016
C. Draijer, C. Boorsma, C. Reker-Smit, E. Post, K. Poelstra, B. Melgert   +5 more
semanticscholar   +1 more source

Association of Circulating Fatty Acid Profiles With Cardiovascular and All‐Cause Mortality in the General Population: A Cohort Study

eFood, Volume 6, Issue 3, June 2025.
ll‐cause and cause‐specific mortality risks associated with lower saturated fatty acids (SFA) and higher monounsaturated fatty acids (MUFA) levels. Low levels of circulating SFAs were associated with an increased risk of all‐cause mortality among American adults, whereas circulating MUFAs were linked to elevated mortality risk at both high and low ...
Xiaogang Lv, Qianqian Ji, Qi Liu, Qingya Zhao, Yue Xu, Yaxian Meng, Liqiong Zhou, Zhao Hu, Na Wang, Yiqiang Zhan   +9 more
wiley   +1 more source

Functional characterization of eicosanoid signaling in Drosophila development. [PDF]

PLoS Genet
Fujinaga D, Nolan C, Yamanaka N.
europepmc   +1 more source

Platelets: Novel Biomaterials for Cancer Diagnosis and Therapeutic Delivery

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
Platelets, particularly tumor‐educated platelets (TEPs), play a crucial role in cancer diagnosis and treatment. TEPs undergo molecular changes in RNA and protein profiles, making them valuable biomarkers for diagnosis, prognosis, and monitoring. In nanomedicine, platelets serve as drug carriers in tumor‐targeted nanomaterials, enhancing specificity and
Xin Wang, Jie Chen, Hubing Shi
wiley   +1 more source

Activation of notch signaling pathway is a potential mechanism for mucin2 reduction and intestinal mucosal barrier dysfunction in high-altitude hypoxia. [PDF]

Sci Rep
Jia R, Han Y, Zhu Q, Zhang J, Zhang H, Ka M, Ma Y, Gamah M, Zhang W.   +8 more
europepmc   +1 more source