Results 271 to 280 of about 158,535 (386)

Systemic EP4 receptor agonist and Arginase‐1 therapy in a murine model of chronic asthma and influenza virus‐induced asthma exacerbation

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 12, Page 2803-2820, June 2025.
Background and Purpose Myeloid‐derived suppressor cells (MDSCs) play important roles in the pathogenesis of asthma. Recent studies demonstrate that their function can be modulated by different pharmacological approaches. In this study, we focussed on the effects of systemically administered prostaglandin EP4 receptor agonist L‐902,688 and pegylated ...
Tim Lange   +7 more
wiley   +1 more source

Eicosapentaenoic Acid, a n-3 Polyunsaturated Fatty Acid Differentially Modulates TNF-α, IL-1α, IL-6 and PGE2 Expression in UVB-Irradiated Human Keratinocytes

open access: bronze, 2002
Annemie Pupe   +6 more
openalex   +1 more source

Inhibition of the RNA Regulator HuR Mitigates Spinal Cord Injury by Potently Suppressing Post‐Injury Neuroinflammation

open access: yesThe FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Delivery of SRI‐42127 after spinal cord injury blocks HuR nucleocytoplasmic translocation in microglia and astrocytes to suppress key neuroinflammatory mediators at the site of injury including, IL‐1β, IL‐6, TNF‐α, COX‐2, INOS, and CCL2. In parallel, there is a reduction of peripheral inflammatory responses in the spleen, liver, and circulation.
Mohammed Amir Husain   +14 more
wiley   +1 more source

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