Results 271 to 280 of about 133,795 (342)

Bone Marrow Mesenchymal Stem Cell Hydrogel‐Mediated Fibroblast Reprogramming Restores Intestinal Function in Adhesive Small Bowel Obstruction

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Conceptual diagram and schematic illustration of microenvironmental changes in individuals with ASBO before and after treatment. BMSC@Gel therapy transforms the ASBO microenvironment from an inflammatory, fibrotic state with aberrant matrix deposition and barrier dysfunction to a regenerative state with reduced inflammation and improved structural ...
Lihong Zheng *, Junrong Zhang *, Zhengyuan Huang *, Zhenliang Lin, Jin Zhang, Da Zhang, Ping Hou, Xianqiang Chen   +7 more
wiley   +1 more source

Potential pharmacological quality control markers in the traditional Japanese medicine Hangeshashinto: identifying anti-inflammatory ingredients through a cell-based bioassay and multicomponent analysis. [PDF]

Pharm Biol
Imai R, Muraki Y, Nishi A, Ohbuchi K.
europepmc   +1 more source

Formation of the early canine CL and the role of prostaglandin E2 (PGE2) in regulation of its function: An in vivo approach

, 2014
Mariusz P. Kowalewski, Stephan J. Ihle, Marta Siemieniuch, Aykut Gram, Alois Boos, S. Zduńczyk, J. Fingerhut, Bernd Hoffmann, Gerhard Schüler, Andrzej Jurczak, Anna Domosławska, T. Janowski   +11 more
openalex   +1 more source

12‐HETE is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, Volume 13, Issue 5, 27 January 2026.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source

Genome-wide CRISPR screening reveals a PKA-driven resistance mechanism to metformin for oral cancer prevention that can be exploited by combination with NSAIDs. [PDF]

Cancer Prev Res (Phila)
Hoang TS, Faraji F, Mendez-Molina AN, Adame-Garcia SR, Sato K, Ishikawa T, Vo PTT, Ramirez SI, Anguiano Quiroz PY, Guo T, Fan K, Wu X, Molinolo AA, Cohen EEW, Mali P, Lippman SM, Gutkind JS.   +16 more
europepmc   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Prostaglandin E₂ stimulates opposing effects on inner and outer blood-retina barrier function. [PDF]

Front Pharmacol
Stark AK, Gilmartin AR, Ontko CD, Smith TE, Beall AL, McCollum GW, Penn JS.   +6 more
europepmc   +1 more source

Fabp5 Is the Key Regulator Mediating γ‐CEHC Differentiation in Osteoblasts and Osteoclasts

BioFactors, Volume 52, Issue 1, January/February 2026.
γ‐CEHC, as a natural Fabp5 inhibitor, ameliorates the osteoporotic microenvironment through a triple‐action mechanism—targeting Fabp5 inhibition → modulating macrophage polarization → balancing bone metabolism—highlighting its translational medical value.
Cheng Cheng, Rong Chen, Minjuan Li, Shuai Lu, Xinping Li, Gengli Cui, Hailing Chen, Xieyuan Jiang   +7 more
wiley   +1 more source

Mechanisms of Pilocarpine-Induced Nitric Oxide and Prostaglandin Production in Porcine Ciliary Muscle. [PDF]

FASEB Bioadv
Benozzi G, Quinteros Villarruel E, Zuluaga AF, Orman B.   +3 more
europepmc   +1 more source