Results 71 to 80 of about 89,482 (299)

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao   +2 more
wiley   +1 more source

KORELASI ANTARA SKALA NYERI, KADAR PGE2 SERUM DAN EKSPRESI PGE2 RESEPTOR EP3 DARAH HAID DENGAN DERAJAT ENDOMETRIOSIS [PDF]

open access: yes, 2019
Nyeri dan infertilitas adalah dua gejala klinis yang menjadi keluhan utama penderita endometriosis. Endometriosis adalah estrogen-dependent dan penyakit ginekologi inflamasi progesterone resistant dari usia reproduksi wanita.
YATI ISNAINI SAFITRI, NIM011314653018
core   +1 more source

Untersuchung der Rolle der PGE2/15-keto-PGE2/EP2/EP4-Achse in der Nierenbiologie und bei Nierenerkrankungen [PDF]

open access: yes
Albuminuria represents a hallmark of both early kidney injury and chronic kidney disease (CKD). The importance of albuminuria as a prognosis marker is demonstrated by recent observations showing the high correlation of albuminuria with the probability of
Kourpa, Aikaterini
core   +1 more source

The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors

open access: yes, 2017
The endocannabinoids 2-arachidonoyl-glycerol and N-arachidonoyl-ethanolamine mediate an array of pro- and anti-inflammatory effects. These effects are related, in part, to their metabolism by eicosanoid biosynthetic enzymes.
Michel Laviolette   +8 more
core   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models

open access: yesDisease Models & Mechanisms, 2022
Jimena Monzón-Sandoval   +8 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

open access: yesBMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu   +5 more
wiley   +1 more source

Cyclosporin A inhibits PGE2 release from vascular smooth muscle cells [PDF]

open access: yes, 1987
The influence of the fungoid undecapeptide cyclosporin A (CyA) on PGE2 release from cultured rat aortic smooth muscle cells was investigated in this study.
Kurtz, Armin   +3 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

open access: yesBMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma   +8 more
wiley   +1 more source

TLR Signalling Pathways Diverge in Their Ability to Induce PGE2 [PDF]

open access: yes, 2016
PGE2 is a lipid mediator abundantly produced in inflamed tissues that exerts relevant immunoregulatory functions. Dendritic cells (DCs) are key players in the onset and shaping of the inflammatory and immune responses and, as such, are well known PGE2 ...
GIANELLO, VERONICA   +13 more
core   +1 more source

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