Results 91 to 100 of about 89,482 (299)
PGE2-induced colon cancer growth is mediated by mTORC1.
, 2014 The inflammatory prostaglandin E2 (PGE2) cytokine plays a key role in the development of colon cancer. Several studies have shown that PGE2 directly induces the growth of colon cancer cells and furthermore promotes tumor angiogenesis by increasing the ...
Dormond-Meuwly, A. +4 more
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Aged PGDH KO mice display elevated PGE2.
, 2022 (A-D) PGE2 levels were quantified in bone marrow (BM), spleen, lung, and colon tissue lysates obtained from 12-15-month-old FVB wildtype littermate (WT), and 15-PGDH knockout (KO) mice. N = 4 female mice/group for BM, Spleen and Lung.
Lakshmi Kasturi (12569063) +12 more
core +1 more source
Journal of the Science of Food and Agriculture, EarlyView.Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen +2 more
wiley +1 more source
Redox Biology, 2019 Overproduction of prostaglandin E2 (PGE2) has been linked to enhanced tumor cell proliferation, invasiveness and metastasis as well as resistance to apoptosis.
Eun Ji Lee +10 more
doaj +1 more source
Intranephron PGE2 production in stroke-prone spontaneously hypertensive rats
, 1990 To investigate whether intranephron prostaglandin E2 (PGE2) production in stroke-prone spontaneously hypertensive rats (SHRSP) differs from that in Wistar-Kyoto rats (WKY), we measured PGE2 accumulation rates in microdissected nephron segments from 4 ...
K. Shimamura +4 more
core +1 more source
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source
Frontiers in Microbiology, 2013 Francisella tularensis is the causative agent of tularemia. We have previously shown that infection with F. tularensis Live Vaccine Strain (LVS) induces macrophages to synthesize prostaglandin E2 (PGE2). Synthesis of PGE2 by F.
Matthew Dale Woolard +8 more
doaj +1 more source
The Journal of Pathology, EarlyView.Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi +8 more
wiley +1 more source
Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland
Journal of Lipid Research, 2005 The mammary gland, like most tissues, produces measurable amounts of prostaglandin E2 (PGE2), a metabolite of arachidonic acid produced by sequential actions of two cyclooxygenases (COX-1 and COX-2) and three terminal PGE synthases: microsomal ...
Subhashini Chandrasekharan +5 more
doaj +1 more source
The PGE2-Stat3 interaction in doxorubicin-induced myocardial apoptosis [PDF]
, 2017 Aims Both cyclooxygenase-2 (COX-2) and the transcription factor signal transducer and activator of transcription 3 (Stat3) are involved in adaptive growth and survival of cardiomyocytes. In ventricular cardiomyocytes, prostaglandin E2 (PGE2), a major COX-
Frias, Miguel A. +5 more
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