Results 111 to 120 of about 89,482 (299)

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Vaginal Misoprostol Compared to Vaginal Dinoprostone for Induction of Labour: A Systematic Review and Meta‐Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Introduction Induction of labour is a common intervention. The prostaglandin dinoprostone is often used, but there is increasing evidence that misoprostol may be more effective without compromising safety. This review compares the efficacy and safety of vaginal misoprostol and vaginal dinoprostone.
Georgina Andersson, Benjamin Greenfield, Alexandra Hunt, Amr Malawany, Ben Luke Choo, William Dixon, David Lissauer, Andrew D. Weeks, Andrew Sharp, Gemma Clayton, Abi Merriel   +10 more
wiley   +1 more source

Sodium Diclofenac‐Loaded Drug Delivery Microspheres: Impact on Calcium Hydroxide Paste Properties and Biological Response

Australian Endodontic Journal, EarlyView.
ABSTRACT This study evaluated whether the incorporation of sodium diclofenac‐loaded microspheres into a calcium hydroxide paste enhances antibiofilm activity while maintaining physicochemical properties and biocompatibility. Calcium hydroxide paste, calcium hydroxide combined with sodium diclofenac, and calcium hydroxide containing sodium diclofenac ...
João Vitor Oliveira de Amorim, Murilo Priori Alcalde, Leonardo Cabau, Rodrigo Ricci Vivan, Paulo Henrique Weckwerth, Marco Antonio Hungaro Duarte, Guilherme Ferreira da Silva   +6 more
wiley   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Pathogenic Airway Bacteria and Local Immune Responses During Early‐Life Asthma‐Like Episodes

Allergy, EarlyView.
This study investigates how Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis associate with airway immune responses during early‐life asthma‐like episodes, and compare these responses between children with and without asthma.
Mathilde Bundgaard Svendsen, Tamo Sultan, Anton Kjellberg, Mathias Melgaard, Susanne Brix, Karen Krogfelt, Nilo Vahman, Ann‐Marie Malby Schoos, Jakob Stokholm, Bo Lund Chawes, Klaus Bønnelykke, Jonathan Thorsen, Julie Nyholm Kyvsgaard   +12 more
wiley   +1 more source

In-vitro and In-vivo Antiarthritic Activity of the Ethanol Extracts of Leaves of Astragalus glycyphyllos in CFA-induced Arthritis in Rats

BioResources
The effectiveness of the ethanolic extract of A. glycyphyllos leaves was evaluated for treating arthritis. This was done by examining its ability to protect chondrocytes (cartilage cells) from inflammation caused by IL-1β stimulation, as well as its ...
Lingli Gu, Rong Su, Shiyun Yin, Yuanjie Zhou, Lili Chen, Weichao Liu, Weitian Yan, Xianna Yang, Jianmei Yin, Jiangyun Peng, Wei Jian Zhou   +10 more
doaj  

G-003M blocked prostaglandin E2 (PGE2) production in mice jejunum.

, 2016
(A) PGE2 generation was measured by using PGE2 ELISA Kit at different time intervals following 9 Gy TBI in C57BL/6J mice jejunum. (B) G-003M pre-treatment suppressed the production of PGE2 (ng/ml) at 2 hr, 6 hr and 24 hr time intervals post-irradiation ...
Manju Lata Gupta (3609383), Abhinav Singh (358909), Sania Bajaj (3609386), M. H. Yashavarddhan (3609380), Bhargab Kalita (614636), Rajiv Ranjan (329421)   +5 more
core   +1 more source

Mesenchymal Stem Cells From a Klinefelter Syndrome Patient: Functional Characterization and Therapeutic Implications

Andrology, EarlyView.
ABSTRACT Background Cell therapy, particularly those utilizing mesenchymal stem/stromal cells (MSCs), is gaining traction as a therapeutic option for regenerative treatment in patients with limited therapeutic options. Although the safety of MSC‐based interventions is well established, uncertainties remain regarding how genetic abnormalities and ...
Marzena Zychowicz, Wioletta Lech, Anna Figiel‐Dabrowska, Marta Kot, Magdalena Murzyn, Natalia Malawska, Barbara Pienkowska‐Grela, Zuzanna Sandowska‐Markiewicz, Iwona Ziolkowska‐Suchanek, Agnieszka Zimna, Tomasz Oldak, Natalia Rozwadowska, Anna Sarnowska   +12 more
wiley   +1 more source

Circulating prostaglandin E2 concentrations decrease at birth in premature lambs

Frontiers in Pediatrics
RationaleDuring pregnancy, prostaglandin E2 (PGE2) is released from the placenta and circulates in relatively high concentrations in the fetus. As PGE2 suppresses breathing, PGE2 concentrations must decrease after birth, but the timing and mechanisms ...
Timothy J. R. Panneflek, Janneke Dekker, Kelly J. Crossley, Kelly J. Crossley, Cailin Diedericks, Cailin Diedericks, Kristel L. A. M. Kuypers, Ebony R. Cannata, Ebony R. Cannata, Paige J. Riddington, Paige J. Riddington, Femmie E. Bloem, Alison M. Thiel, Alison M. Thiel, Thomas van den Akker, Thomas van den Akker, Graeme R. Polglase, Graeme R. Polglase, Arjan B. te Pas, Stuart B. Hooper, Stuart B. Hooper, Indya M. Davies, Indya M. Davies   +22 more
doaj   +1 more source

mPGES1-Dependent Prostaglandin E2 (PGE2) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE2 Production

, 2018
The integration of inflammatory signals is paramount in controlling the intensity and duration of immune responses. Eicosanoids, particularly PGE2, are critical molecules in the initiation and resolution of inflammation and in the transition from innate ...
Lindsay E. Nyhoff, David D. Brand, Bridgette Baron, Fumiaki Kojima, Elizabeth M. Johnson, Jerold G. Woodward, Martin R. Ward, Ashley J. Wilhelm, Damian Maseda, Leslie J. Crofford   +9 more
core   +1 more source