Results 1 to 10 of about 5,671 (109)

Genetic counseling for pre-implantation genetic testing of monogenic disorders (PGT-M) [PDF]

Frontiers in Reproductive Health, 2023
Pre-implantation genetic testing (PGT) is a vital tool in preventing chromosomal aneuploidies and other genetic disorders including those that are monogenic in origin. It is performed on embryos created by intracytoplasmic sperm injection (ICSI). Genetic
Firuza Parikh, Arundhati Athalye, Prochi Madon, Meenal Khandeparkar, Dattatray Naik, Rupesh Sanap, Anuradha Udumudi   +6 more
doaj   +2 more sources

Simultaneous detection of genomic imbalance in patients receiving preimplantation genetic testing for monogenic diseases (PGT-M) [PDF]

Frontiers in Genetics, 2022
Background: Preimplantation genetic test for monogenic disorders (PGT-M) has been used to select genetic disease-free embryos for implantation during in vitro fertilization (IVF) treatment.
Lin Yang, Lin Yang, Yan Xu, Yan Xu, Jun Xia, Jun Xia, Huijuan Yan, Chenhui Ding, Chenhui Ding, Qianyu Shi, Yujing Wu, Ping Liu, Jiafu Pan, Jiafu Pan, Yanhong Zeng, Yanhong Zeng, Yanyan Zhang, Fang Chen, Hui Jiang, Yanwen Xu, Yanwen Xu, Wei Li, Wei Li, Canquan Zhou, Canquan Zhou, Ya Gao, Ya Gao   +26 more
doaj   +2 more sources

Outcomes and the effect of PGT-M in women with hormone-related hereditary tumor syndrome [PDF]

Frontiers in Oncology
PurposeTo review the outcome of PGT-M in hormone-related hereditary tumor syndrome and evaluate the effect of ovarian induction on tumor growth in those patients.MethodsMedical records of PGT-M were retrospectively analyzed in patients with hormone ...
Dingran Wang, Xueling Song, Xiaohui Zhu, Liying Yan, Xu Zhi, Jie Yan, Huamao Liang, Jie Qiao   +7 more
doaj   +2 more sources

The Role of Preimplantation Genetic Testing for Monogenic Disorders (PGT-M) in Hemoglobinopathy Management—Techniques, Accuracy, and the Balancing of Benefits and Drawbacks [PDF]

Biomolecules
Preimplantation genetic testing for monogenic disorders (PGT-M) is a powerful tool for identifying genetic disorders prior to gestation. For hemoglobinopathies like thalassemias and sickle cell disease, PGT-M offers a preventative strategy to ensure that
Rasrawee Chantrasiri, Tawiwan Pantasri, Siriporn Chattipakorn, Nipon Chattipakorn, Sirinart Kumfu, Wirawit Piyamongkol   +5 more
doaj   +2 more sources

An overview of the current and emerging platforms for preimplantation genetic testing for aneuploidies (PGT-A) in in vitro fertilization programs

Taiwanese Journal of Obstetrics and Gynecology, 2020
Preimplantation genetic testing for aneuploidies (PGT-A) and PGT for monogenic disorders (PGT-M) have currently been used widely, aiming to improve IVF outcomes.
Hsin-Fu Chen, Hong-Nerng Ho
exaly   +3 more sources

Clinical Outcome, Socioeconomic Status and Psychological Constrains of Patients Undergoing Preimplantation Genetic Testing (PGT) in Northern Greece

Medicina (Lithuania), 2022
Background and objectives: Preimplantation genetic testing (PGT) offers patients the possibility of having a healthy baby free of chromosomal or genetic disorders.
Alexandra Papadopoulou, Christos Noutsos, Panagiotis Tzekis   +2 more
exaly   +3 more sources

Case Report: Preventing X-linked retinoschisis transmission via MARSALA-based PGT-M [PDF]

Frontiers in Ophthalmology
X-linked retinoschisis (XLRS) is an X-linked recessive inherited retinal disease caused by mutations in the RS1 gene. This case report describes the successful application of preimplantation genetic testing for monogenic diseases (PGT-M) to prevent the ...
Jieliang Li, Xiaojun Wen, Zhanhui Ou, Xiaowu Fang, Jing Du, Xiufeng Lin, Xiufeng Lin, Wanna Ke, Jiaqi Wu, Nengqing Liu   +9 more
doaj   +2 more sources

Factors associated with de novo aneuploidy across different preimplantation genetic testing cycles: a retrospective cohort study [PDF]

Frontiers in Endocrinology
ObjectivePrevious studies on factors influencing embryonic aneuploidy have produced inconsistent results. This study aimed to identify predictors of de novo aneuploidy in distinct patients undergoing preimplantation genetic testing for structural ...
Hongfang Liu, Hongfang Liu, Hongxing Li, Hongxing Li, Xiaojuan Xu, Xiaojuan Xu, Aiping Zhang, Aiping Zhang, Bin Mao, Bin Mao, Xiaoling Ma, Xiaoling Ma   +11 more
doaj   +2 more sources

Development of pre-implantation genetic testing protocol for monogenic disorders (PGT-M) of Hb H disease [PDF]

BMC Genomics
Hb H disease is the most severe form of α-thalassemia compatible with post-natal life. Compound heterozygous α0-thalassemia− SEA deletion/α+-thalassemia− 3.7kb deletion is the commonest cause of Hb H disease in Thailand.
Pannarai Somboonchai, Pimlak Charoenkwan, Sirivipa Piyamongkol, Worashorn Lattiwongsakorn, Tawiwan Pantasri, Wirawit Piyamongkol   +5 more
doaj   +2 more sources

Specialist physicians’ referral behavior regarding preimplantation genetic testing for single-gene disorders: Is there room to grow?

F&S Reports, 2021
Objective: To assess whether primary care specialists’ demographics, specialty, and knowledge of preimplantation genetic testing for monogenic disorders (PGT-M) influence their practice patterns. Design: Cross-sectional survey study.
Sarah Capelouto, M.D., Melanie Evans, M.D., Jennifer Shannon, M.D., Katelyn Jetelina, Ph.D., M.P.H., Orhan Bukulmez, M.D., Bruce Carr, M.D.   +5 more
doaj   +1 more source