Results 41 to 50 of about 296,899 (292)

pH-Responsive DNA Motif: From Rational Design to Analytical Applications

Frontiers in Chemistry, 2021
pH-responsive DNA motifs have attracted substantial attention attributed to their high designability and versatility of DNA chemistry. Such DNA motifs typically exploit DNA secondary structures that exhibit pH response properties because of the presence ...
Lin Lin Zheng, Jin Ze Li, Ying Xu Li, Jian Bang Gao, Jiang Xue Dong, Zhong Feng Gao   +5 more
doaj   +1 more source

Flow of pH-responsive microcapsules in porous media [PDF]

, 2015
This article investigates the use micro-capsules, containing a gelling agent hydroxypropyl cellulose (HPC), to alter flow paths in porous media. The aim is to preferentially block-off high permeability regions, thereby diverting the flow into adjacent un-

core   +1 more source

Electrostatically gated membrane permeability in inorganic protocells [PDF]

, 2013
Although several strategies are now available to produce functional microcompartments analogous to primitive cell-like structures, little progress has been made in generating protocell constructs with self-controlled membrane permeability.
A Boker, A Dzieciol, A Pohorille, AB Subramaniam, AB Subramaniam, AD Dinsmore, B Städler, Bernard P. Binks, C Wu, D Lee, DS Williams, DY Wang, GJT Cooper, J-W Kim, Jonathan V. M. Weaver, JVM Weaver, JW Szostak, KL Thompson, M Li, Mei Li, MF Hsu, P Stano, P Stano, P Walde, Rachel L. Harbron, RK Shah, RL Harbron, S Koga, S Mann, Stephen Mann, W Martin   +30 more
core   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Ph-Responsive Immunomodulatory Hydrogel For Periodontitis

International Dental Journal
Aim or purpose: Targeting periodontitis from plaque biofilms causing tissue damage and acidity, and poor conventional drug delivery, this study developed a pH-responsive injectable hydrogel to suppress inflammation via pH-triggered release, providing a ...
Yi Zheng, Tianyi Zhang, Mengru Guo
doaj   +1 more source

Advances in pH-responsive drug delivery systems

OpenNano, 2021
Bioresponsive nanosystems are increasingly important in a wide range of applications such as drug delivery, tissue engineering, imaging diagnostics and biosensors.
Yongxu Mu, Lidong Gong, Tianjiao Peng, Jun Yao, Zhiqiang Lin   +4 more
doaj   +1 more source

Superelastic and pH-Responsive Degradable Dendrimer Cryogels Prepared by Cryo-aza-Michael Addition Reaction [PDF]

, 2018
Dendrimers exhibit super atomistic features by virtue of their well-defined discrete quantized nanoscale structures. Here, we show that hyperbranched amine-terminated polyamidoamine (PAMAM) dendrimer G4.0 reacts with linear polyethylene glycol (PEG ...
Wang, Juan, Yang, Hu
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

pH-Responsive Nanoparticles for Drug Delivery [PDF]

Molecular Pharmaceutics, 2010
First-generation nanoparticles (NPs) have been clinically translated as pharmaceutical drug delivery carriers for their ability to improve on drug tolerability, circulation half-life, and efficacy. Toward the development of the next-generation NPs, researchers have designed novel multifunctional platforms for sustained release, molecular targeting, and
Weiwei, Gao, Juliana M, Chan, Omid C, Farokhzad   +2 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source