Results 191 to 200 of about 3,645,606 (296)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Adaptive Polymers: The pH-Responsive Revolution in Biomedical Materials. [PDF]

ACS Omega
Musale S, Jarande S, Nikam A, Pawar R, Kodange NN, Kapare H, Nison M, Pai VR, Aher AA, Datta D, Giram P.   +10 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Factors Influencing Physical Activity Engagement Amongst Those Living With Pulmonary Hypertension in the UK. [PDF]

Pulm Circ
Hardcastle SJ, Wells Z, Keen C, Condliffe R, Kiely DG, McCormack C.   +5 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Portada Vol. 14, núm. 1 (2000)

Philologia Hispalensis, 2000
PH PH
doaj  

Design, synthesis and response surface optimization of a high-performance LaFeO₃/Mg-Al layered double hydroxide/chitosan ternary nanocomposite as a pH-responsive carrier for controlled celecoxib release: experimental evaluation and kinetic modeling. [PDF]

RSC Adv
Moradi Kozaraji S, Mousavi SM, Setoodehkhah M.   +2 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Cover Vol. 30, no. 2 (2016)

Philologia Hispalensis, 2016
PH PH
doaj  

The Influence of SPI 7S and 11S on the Stability of <i>Lonicera caerulea</i> L. Anthocyanins and Interaction Mechanism with C3G. [PDF]

Foods
Zhou Y, Yuan Y, Wang Z, Wu D, Du Y, Hu J.   +5 more
europepmc   +1 more source