Results 201 to 210 of about 3,645,606 (296)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Effect of Electron-Withdrawing Substituents on Raman Spectra of Diaryl-BTBT Derivatives. [PDF]

Int J Mol Sci
Parashchuk OD, Poletavkina LA, Vener MV, Dyadishchev IV, Luponosov YN, Borshchev OV, Korchkova SN, Ponomarenko SA, Paraschuk DY, Sosorev AY.   +9 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

pH do solo

Through an experience involving a purple cabbage it determines the soil's pH in different samples and observes the acid, basic and neutral pHComponente Curricular::Ensino Fundamental::Séries Finais::Ciências ...
Lima, Marcelo Ricardo de, Yoshioka, Maria Harumi   +1 more
core  

Role of E. coli acid resistance systems in proton motive force formation during fermentation. [PDF]

Biophys Rep (N Y)
Gevorgyan H, Abaghyan T, Hakobyan S, Brameyer S, Jung K, Trchounian K.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Reviewers Vol. 30, no. 1 (2016)

Philologia Hispalensis, 2016
PH PH
doaj  

PHS Responsibilities

Public Health Reports (1896-1970), 1956
openaire   +2 more sources

Pulmonary vasodilator therapy in COPD-associated pulmonary hypertension: A real-world case series of 14 patients confirmed by right heart catheterization. [PDF]

Respir Med Case Rep
Vera Ricaurte M, Kosak Lopez E, Geller A, Leguizamon R, Lam J, Srikulmontri T, Helena Siqueira Tavares de Melo M, Stavola T, Malin J, Martinez-Manzano JM, Pacheco E.   +10 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source