Results 221 to 230 of about 7,386,473 (331)
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama+7 more
wiley +1 more source
Phenotyping of patients with mild pulmonary hypertension. [PDF]
Dardi F+9 more
europepmc +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
An active allosteric mechanism in ASAP1-mediated Arf1 GTP hydrolysis redefines PH domain function. [PDF]
Soubias O+12 more
europepmc +1 more source
Effect of sodium chloride on the pH of p-phenolsulfonate buffers from 0 degrees to 60 degrees C
R.G. Bates, S. F. Acree
openalex +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez+5 more
wiley +1 more source
The Correlation Between NLR, RDW, and Pulmonary Hypertension in Patients With Bronchiectasis and Chronic Obstructive Pulmonary Disease Overlap Syndrome. [PDF]
Hu L, Liu Z, Yu J, Yang Z, Feng D.
europepmc +1 more source